Dabrafenib Plus Trametinib vs Vemurafenib Alone in Unresectable or Metastatic BRAF V600E/K Cutaneous Melanoma

Completed · Phase 3

Conditions studied: Melanoma

In brief

This was a two-arm, open-label, randomized, Phase III study comparing dabrafenib (GSK2118436) and trametinib (GSK1120212) combination therapy with vemurafenib.

Key facts

Study ID

NCT01597908

Run by

Novartis Pharmaceuticals

People needed

704

Starts

2012-06-04

Expected to finish

2019-04-25

Last updated by the study team

2021-02-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Novartis Investigative Site — Gilbert, Arizona, United States
• Novartis Investigative Site — Beverly Hills, California, United States
• Novartis Investigative Site — San Francisco, California, United States
• Novartis Investigative Site — Vallejo, California, United States
• Novartis Investigative Site — Aurora, Colorado, United States
• Novartis Investigative Site — Jacksonville, Florida, United States
• Novartis Investigative Site — Miami Beach, Florida, United States
• Novartis Investigative Site — Orlando, Florida, United States
• Novartis Investigative Site — Atlanta, Georgia, United States
• Novartis Investigative Site — Atlanta, Georgia, United States
• Novartis Investigative Site — Iowa City, Iowa, United States
• Novartis Investigative Site — Ann Arbor, Michigan, United States
• Novartis Investigative Site — Fridley, Minnesota, United States
• Novartis Investigative Site — St Louis, Missouri, United States
• Novartis Investigative Site — Las Vegas, Nevada, United States
• Novartis Investigative Site — Hackensack, New Jersey, United States
• Novartis Investigative Site — New Brunswick, New Jersey, United States
• Novartis Investigative Site — New York, New York, United States
• Novartis Investigative Site — Chapel Hill, North Carolina, United States
• Novartis Investigative Site — Charlotte, North Carolina, United States
• Novartis Investigative Site — Durham, North Carolina, United States
• Novartis Investigative Site — Cincinnati, Ohio, United States
• Novartis Investigative Site — Columbus, Ohio, United States
• Novartis Investigative Site — Bend, Oregon, United States
• Novartis Investigative Site — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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