Exercise Study of Function and Pathology for Women With X-linked Adrenoleukodystrophy

Completed · Not applicable

Conditions studied: X-linked Adrenoleukodystrophy

In brief

The purpose is to see how X-linked adrenoleukodystrophy (X-ALD) is associated with strength and sensation using MRI, in women with X-ALD. The investigators will also see whether exercise can improve these symptoms for women with X-ALD.

Key facts

Study ID

NCT01594853

Run by

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

People needed

31

Starts

2012-05-01

Expected to finish

2014-10-01

Last updated by the study team

2018-08-29

Who can join

Age: 21 and older, up to 70. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• confirmed diagnosis, X-ALD heterozygote carrier
• no medical contraindication to participating in a strength training program
• able to follow complex directions as determined by a score of ≤1 on a subset of questions taken from the NIH Stroke scale (Brott et al. 1989)
• hip flexion strength: 6.6-15.8kg
• hip extension strength: up to 18.3 kg
• normal passive range of motion at hips/knees/ankles
• able to walk ≥50m

You may not qualify if…

• Evidence of other neurological deficit that could interfere, such as previous stroke or muscle disease
• congestive heart failure
• cancer
• orthopedic conditions
• severe pain that precludes study participation
• seizures
• pregnancy
• other medical condition that precludes participation in an exercise program, e.g., unstable angina, uncontrolled diabetes, uncontrolled hypertension
• Healthy controls have the same age and exclusion criteria as women with AMN except that they will not be carriers for X-ALD. They must have normal neurological function.

Where it is running

• Motion Analysis Lab — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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