Effects of Hemoperitoneum Driven Carbon Monoxide on Post-Traumatic Stability and Platelet Aggregation

Completed

Conditions studied: Hemoperitoneum

In brief

Our objective is to determine whether or not the presence of hemoperitoneum in trauma patients is associated with increased Carbon Monoxide (CO) formation, and to determine if elevated Carbon Monoxide levels are associated with cardiovascular depression, impaired platelet aggregation, and/or multiple organ failure.

Key facts

Study ID

NCT01594034

Run by

The University of Texas Health Science Center at San Antonio

People needed

9

Starts

2009-11-01

Expected to finish

2011-05-01

Last updated by the study team

2012-05-14

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Hospitalized males 18 years of age or older,
• Diagnosis of isolated blunt OR blunt and penetrating trauma,
• Admitted or expecting to be admitted to the Intensive Care Unit,
• On mechanical ventilation, and
• Written informed consent obtained

You may not qualify if…

• Female gender, (Females will be excluded from this study as the menstrual cycle and other estrogen variations are known to be associated with cyclic changes in CO production adding a potential confounder to the interpretations of our findings.)
• Diagnosis of isolated penetrating trauma,
• Acute hemothorax or pneumothorax,
• Treatment with antiaggregants (ASA, clopidogrel, aggrenox or ticlopidine),
• Enrollment in another research study,
• Prisoners,
• Inability to perform CO measurement within 96 hours after hospital admission.

Where it is running

• University Hospital — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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