How Does Magnesium Status Influence Calcium Homeostasis?
Completed · Phase 4 · Has a placebo group
Conditions studied: Magnesium Deficiency, Calcium Metabolism Disorders
In brief
The investigators aim to recruit 60 women who have agreed to participate in an existing randomized, double-blind, placebo-controlled trial (Treatment of Vitamin D Insufficiency, HSC 2009-0055). In this trial, the investigators propose to evaluate the associations between magnesium intake, magnesium stores, fractional magnesium absorption and calcium homeostasis. The investigators will stratify 60 subjects in the sub-study, ensuring that approximately 20 subjects are randomized into each treatment arm (placebo, low-dose and high-dose vitamin D). The investigators already assess calcium homeostasis throughout the study by measuring bone mineral density, fractional calcium absorption, serum and urine calcium levels, among other tests. In the sub-study of 60 women, the investigators will evaluate whether habitually higher magnesium intake increases or decreases fractional calcium absorption. The investigators will evaluate the interplay between magnesium stores, vitamin D levels and serum parathyroid hormone levels. The investigators will directly assess magnesium stores using serum magnesium and 24-hour urine magnesium levels, and will measure magnesium absorption using the dual stable isotope approach.
Key facts
- Study ID
- NCT01593501
- Run by
- University of Wisconsin, Madison
- People needed
- 39
- Starts
- 2012-05-01
- Expected to finish
- 2014-08-01
- Last updated by the study team
- 2016-11-01
Who can join
Age: 30 and older, up to 75. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- participants eligible for the study "Treatment of vitamin D insufficiency" are eligible for participation in the current sub-study
You may not qualify if…
- identical to those covered in HSC #2009-0055
Where it is running
- University of Wisconsin-Madison Hospital, Clinical Research Unit, Osteoporosis Research Center — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
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