Randomized Double Blind Control Trial on Effects of Ranolazine on New Onset Atrial Fibrillation
Stopped early · Not applicable · Has a placebo group
Conditions studied: Atrial Fibrillation New Onset, Hemorrhage, Prolonged QTc Interval, Ventricular Tachycardia, Medical Care; Complications, Late Effect of Complications
In brief
The aim of this study is to evaluate the prophylactic effects of Ranolazine on new onset atrial fibrillation in post-operative coronary artery bypass graft and valve surgery patient population at Staten Island University hospital.
Key facts
- Study ID
- NCT01590979
- Run by
- Northwell Health
- People needed
- 54
- Starts
- 2012-04-01
- Expected to finish
- 2015-06-01
- Last updated by the study team
- 2017-03-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male and female candidates (18 years of age and older) undergoing coronary bypass grafting surgery or valve repair or replacement - Aortic or Tricuspid or Pulmonary valves
- Patients who are not previously on Ranolazine
- Do not have a history of arrhythmia and are not on any antiarrhythmic therapy
- Patients with QTc on a 12 lead EKG of less than or equal to 460 ms
- Patients with estimated Glomerular Filtration Rate (GFR) greater than 30 mL/min/1.73 m2 on the initial lab work
- Available at least 48 hours before surgery
You may not qualify if…
- Patients who are not undergoing above surgeries
- Patients undergoing surgery for mitral valve replacement/repair
- Patient with cirrhosis
- Pregnant patients
- Patients with chronic atrial fibrillation
- Patients who had prior adverse drug reactions or allergies to Ranolazine
- Patients who are already taking Ranolazine prior to the study
- Patient who are reported HIV Positive (as there are antiretroviral drug interactions)
- Patients who are on drugs listed in Appendix A prior to the study
Where it is running
- Staten Island University Hosptial — Staten Island, New York, United States
Full record on ClinicalTrials.gov
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