Validation Durability Adenosine Effect in Verification Pulmonary Vein Isolation

Completed · Not applicable

Conditions studied: Atrial Fibrillation

In brief

Adenosine is used clinically to assess permanency of electrical isolation of pulmonary veins during atrial fibrillation ablation, however, the methodology has not been validated either in terms of the reproducibility of the adenosine response or the effect on clinical outcomes, namely whether using pulmonary vein reconnection to guide additional ablation lowers rate recurrent atrial fibrillation post ablation. Study will test the hypothesis that the response to adenosine used in this manner is reproducible over time.

Key facts

Study ID

NCT01590875

Run by

Medical College of Wisconsin

People needed

20

Starts

2012-05-01

Expected to finish

2015-06-01

Last updated by the study team

2017-11-06

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing atrial fibrillation ablation, pulmonary vein isolation by catheter for standard clinical indications

You may not qualify if…

• allergy or contraindication to adenosine,
• inability to give informed consent,
• currently taking dipyridamole,
• verapamil or theophylline and
• breast-feeding mothers.

Where it is running

• Froedtert Hospital — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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