A Study of the Safety, Tolerability, and Efficacy of IVT Pre-op 0.3mg Pegaptanib Sodium Versus Sham, for Management of Tractional Retinal Detachment and Vitreous Hemorrhage With Proliferative Diabetic Retinopathy

Withdrawn before enrolling · Phase 3 · Has a placebo group

Conditions studied: Proliferative Diabetic Retinopathy

In brief

The purpose of this study is to assess whether preoperative pegaptanib sodium safely improves vitreous hemorrhage prior to surgical intervention and to evaluate the stability of pre-existing tractional retinal detachment.

Key facts

Study ID

NCT01589718

Run by

Greater Houston Retina Research

People needed

0

Starts

2012-04-01

Expected to finish

2014-03-01

Last updated by the study team

2014-03-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Best corrected visual acuity in the study eye between 20/30 and light perception (LP)
• Willingness to provide signed informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization
• Age ≥ 18 years
• For sexually active women of childbearing potential, agreement to the use of an appropriate form of contraception (or abstinence) for the duration of the study

You may not qualify if…

• History of anti-VEGF treatment in the study eye
• History of previous pars plana vitrectomy in the study eye
• Intraocular surgery in the study eye within one month of the study
• Patients with extensive vitreous hemorrhage in conjunction with a rhegmatogenous retinal detachment
• Tractional retinal detachment from causes inconsistent with PDR, such as inflammation or trauma
• Any concurrent intraocular condition in the study eye that could either require medical or surgical intervention during the study period to prevent or treat visual loss that might result from that condition or if allowed to progress untreated could likely contribute to loss of at least 2 Snellen equivalent lines of BCVA over the study period.
• Active intraocular inflammation (grade trace or above) in the study eye
• Active infectious conjunctivitis, keratitis, scleritis, or endophthalmitis in either eye
• Uncontrolled glaucoma in the study eye (defined as IOP≥ 35 mmHg despite treatment with anti-glaucoma medication)
• History of glaucoma-filtering surgery in the study eye
• History of corneal transplant in the study eye

Where it is running

• Retina Consultants of Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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