Studying Chromosomes in Samples From Younger Patients With Neuroblastoma

Completed

Conditions studied: Neuroblastoma

In brief

This research studies chromosomes in samples from younger patients with neuroblastoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

Key facts

Study ID

NCT01589341

Run by

Children's Oncology Group

People needed

300

Starts

2012-04-01

Last updated by the study team

2016-05-18

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Samples from neuroblastoma patients who, according to risk stratification, did not receive cytotoxic treatment and did never receive chemotherapy and are in complete response (CR) OR patients who, according to risk stratification, did not receive cytotoxic treatment initially, but had a localized or a systemic (stage Ms or M) relapse with or without following chemotherapy
• Low-risk Children Oncology Group (COG) designation: no initial cytotoxic treatment, any stage, any age, any outcome
• DNA from untreated neuroblastoma tumor samples (from patients in the age group below and from patients in the age group above 1.5 years of age) available from the COG, Europe, Israel, and Japan
• No MYCN amplification
• No Schwann cell stroma-rich tumors
• No tumor cell content below 60%
• No DOT
• No patients diagnosed before 1997 and after 2005
• No lack of follow-up data
• See Disease Characteristics
• No initial cytotoxic treatment

Where it is running

• Children's Oncology Group — Monrovia, California, United States

Full record on ClinicalTrials.gov

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