Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A
Completed · Phase 3
Conditions studied: Wrinkles
In brief
This study is being done to find out if the use of botulinum toxin prior to a medium strength combination chemical peel (Jessner's peel followed by 35% Trichloroacetic acid peel) will improve the appearance of crow's feet wrinkles when compared to a chemical peel alone. Botulinum toxin type A is a purified substance, derived from a bacteria that block muscular nerve signals. Jessner's Peel, a combination of resorcinol (14g), salicylic acid (14g), and lactic acid (85%) in ethanol (95%), is a superficial chemical peel. These two products/procedures have been FDA approved to improve the appearance of facial wrinkles.
Key facts
- Study ID
- NCT01586819
- Run by
- Loyola University
- People needed
- 26
- Starts
- 2011-09-01
- Expected to finish
- 2013-05-01
- Last updated by the study team
- 2017-09-11
Who can join
Age: 30 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 30 to 75 years old
- In good health
- Has static and dynamic lateral canthal wrinkles ("crow's feet")
- Has the willingness and the ability to understand and provide informed consent and communicate with the investigator
You may not qualify if…
- Pregnant or lactating
- Has received the following treatments:
- botulinum toxin injections in the past 6 months
- ablative laser procedure in the past 6 months
- radiofrequency device treatment in the past 6 months
- ultrasound device treatment in the past 6 months
- medium to deep chemical peel in the past 6 months
- temporary soft tissue augmentation material in the past year
- semi-permanent soft tissue augmentation material in the past 2 years
- permanent soft tissue augmentation material
- Is planning to receive within the next 3 months, any cosmetic procedure (such as any chemical peels, botulinum toxin injections, ablative or non-ablative laser procedures, filler injections, radiofrequency procedures, dermabrasion, ultrasound and face lifting procedures)
- Has an active infection on their face (excluding mild acne
- Has a history of neuromuscular disorders
- Has an allergy to albumin
- Has an allergy to Aquaphor AND petroleum jelly
- Has a history of bleeding disorders
- Is unable to understand the protocol or to give informed consent
- Has a mental illness
Where it is running
- Loyola Dermatology — La Grange Park, Illinois, United States
Full record on ClinicalTrials.gov
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