Intensity-Modulated Radiation Therapy in Treating Younger Patients With Lung Metastases
Completed · Not applicable
Conditions studied: Adult Rhabdomyosarcoma, Lung Metastases, Metastatic Ewing Sarcoma, Previously Treated Childhood Rhabdomyosarcoma, Recurrent Adult Soft Tissue Sarcoma, Recurrent Childhood Rhabdomyosarcoma, Recurrent Wilms Tumor and Other Childhood Kidney Tumors, Stage IV Adult Soft Tissue Sarcoma, Stage IV Wilms Tumor, Stage V Wilms Tumor, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific
In brief
This pilot clinical trial studies intensity-modulated radiation therapy (IMRT) in treating younger patients with lung metastases. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
Key facts
- Study ID
- NCT01586104
- Run by
- Ann & Robert H Lurie Children's Hospital of Chicago
- People needed
- 20
- Starts
- 2011-02-01
- Expected to finish
- 2016-06-02
- Last updated by the study team
- 2025-02-10
Who can join
Age: 1 and older, up to 29. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients may have a Wilms tumor, Ewing Sarcoma, Rhabdomyosarcoma or any other metastatic pediatric malignancy; patients may have a single or multiple pulmonary metastases at the time of diagnosis or at the time of recurrence; a pulmonary metastasis may be defined as one pulmonary nodule >= 1 cm or more than one pulmonary nodules >= 0.5 cm; a biopsy of the nodules may be considered in case of doubt
- The Karnofsky performance status must be >= 50 for patients > 16 years of age and the Lansky performance status must be >= 50 for patients =< 16 years of age
- Patients must not have received prior radiation therapy to any part of the thorax
- Adequate cardiac function defined as:
- Shortening fraction of >= 27% by echocardiogram, or
- Ejection fraction of >= 50% by radionuclide angiogram
- Female patients of childbearing age must have a negative pregnancy test
- Female patients who are lactating must agree to stop breast-feeding
- Sexually active patients of childbearing potential must agree to use effective contraception
You may not qualify if…
- Patients enrolled on Children's Oncology Group protocols cannot be treated with whole lung IMRT on this study
- Patients who have a prior history of radiation therapy to the thorax or adjacent regions cannot be entered on this protocol
- Patient with Hodgkin's Lymphoma are not eligible for this study
- Patients with mediastinal masses or other pulmonary masses requiring additional mediastinal or lung irradiation beyond the whole lung irradiation (WLI) doses stated in this protocol are ineligible for this study
- Patients who may require concurrent or sequential irradiation to sites beyond the chest such as the neck, flank, abdomen or liver are eligible for this study
Where it is running
- Children's Healthcare of Atlanta - Egleston — Atlanta, Georgia, United States
- Ann & Rober H Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
- Riley Hospital for Children — Indianapolis, Indiana, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Children's Hospital of Pittsburgh of UPMC — Pittsburgh, Pennsylvania, United States
- M D Anderson Cancer Center — Houston, Texas, United States
Full record on ClinicalTrials.gov
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