Study of Psychological and Motor Effects of Testosterone in Adolescents With XXY/Klinefelter Syndrome

Completed · Not applicable · Has a placebo group

Conditions studied: Klinefelter Syndrome, XXY Syndrome

In brief

The purpose of this study is to determine if testosterone replacement therapy leads to changes in psychological factors and/or motor skills in adolescent males with 47,XXY (also called Klinefelter syndrome). This study will also evaluate whether certain genetic factors of the X chromosome affect the psychological or motor features of XXY/Klinefelter syndrome.

Key facts

Study ID

NCT01585831

Run by

University of Colorado, Denver

People needed

48

Starts

2012-03-01

Expected to finish

2017-10-01

Last updated by the study team

2021-08-10

Who can join

Age: 8 and older, up to 18. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Males with 47,XXY
• Participants must be in early puberty (Tanner stage II-III)
• Age 8 - 18 will be considered, but eligibility will be determined by review of laboratory results, bone age X-ray, and physical examination to determine stage of puberty
• All racial and ethnic groups

You may not qualify if…

• Other genetic variations of Klinefelter syndrome (48,XXXY, 48,XXYY, 49,XXXXY). The investigator has other studies for these groups and we encourage interested individuals with these disorders to contact us about other available studies.
• 47,XXY plus another genetic disorder
• Non-English speaking individuals (because the psychological tests are administered in English)
• Participants with a medical history of blood clotting problems, blindness, deafness, or cancer

Where it is running

• Childrens Hospital Colorado — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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