B-type Natriuretic Peptide as a Surrogate Marker Guiding Post-operative Fluid Off-loading

Completed · Not applicable

Conditions studied: Fluid Over-load

In brief

The long-range goal of this proposal is to decrease morbidity and mortality related to pulmonary edema and congestive heart failure (CHF) in post-operative patients. The short-range goal is to determine a mechanistic endpoint when therapy for impending heart failure can be initiated and terminated based on B-type natriuretic peptide (BNP) levels. The investigators propose to utilize changing levels of BNP as a surrogate marker for CHF.

Key facts

Study ID

NCT01584518

Run by

Creighton University

People needed

50

Starts

2012-07-01

Expected to finish

2013-06-01

Last updated by the study team

2016-05-27

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• General Surgery patients with history of coronary artery disease, congestive heart failure, pulmonary hypertension
• Cardiac surgery patients undergoing CABG (coronary artery bypass grafting) and valve replacements

You may not qualify if…

• Recent myocardial infarction (within 3 months).
• ASA class 4 and more.
• Emergency surgeries.

Where it is running

• Creighton University Medical Center — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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