Treatment of Residual Amblyopia With Donepezil
Completed · Phase 1
Conditions studied: Amblyopia
In brief
Amblyopia is the leading cause of monocular visual impairment in children and adults. Despite conventional treatment with patching or eye drops, many older children and adults do not achieve normal vision in the amblyopic eye. Donepezil is an acetylcholinesterase inhibitor that increases levels of the neurotransmitter acetylcholine in the brain. Use of acetylcholinesterase inhibitors has been demonstrated by the Hensch lab (Department of Neurology, FM Kirby Neurobiology Center) at Boston Children's Hospital to improve vision and reverse amblyopia in animal models. The purpose of this study is to evaluate the efficacy of oral donepezil as treatment for residual amblyopia (20/50 - 20/400) in patients 8 years of age and older.
Key facts
- Study ID
- NCT01584076
- Run by
- Boston Children's Hospital
- People needed
- 18
- Starts
- 2012-08-01
- Expected to finish
- 2021-01-01
- Last updated by the study team
- 2021-06-18
Who can join
Age: 8 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age ≥8 years
- Amblyopia associated with strabismus and/or anisometropia
- Amblyopic eye visual acuity of 20/50 - 20/400
- Sound eye visual acuity of ≥20/25
- For 8 to 17 year olds, current amblyopia treatment of at least 2 hours of daily patching for at least 4 weeks during the pre-enrollment period with no improvement in best-corrected amblyopic eye visual acuity (<5 letters or 1 logMAR line between 2 consecutive visual acuity measurements at least 4 weeks apart while on current treatment)
- For ≥18 year olds, history of prior amblyopia treatment with patching
- Wearing optimal optical correction with stable amblyopic eye visual acuity (<5 letters or 1 logMAR line of improvement during 2 consecutive visual acuity measurements at least 4 weeks apart)
- Complete eye examination within 6 months prior to enrollment
- Available for at least 6 months of follow-up, have access to a phone, and willing to be contacted by clinical staff
- Likely to comply with prescribed treatment and unlikely, if applicable, to continue to improve with 2 hours of daily patching alone
You may not qualify if…
- Myopia more than -6.00 D spherical equivalent
- Presence of associated findings that could cause reduced visual acuity
- Previous intraocular or refractive surgery
- Strabismus surgery planned within 22 weeks
- Current vision therapy or orthoptics
- Treatment with topical atropine within the past 4 weeks
- Presence of cardiac condition, asthma, obstructive pulmonary disease, seizure disorder, urinary incontinence, and/or peptic ulcer disease receiving concurrent NSAIDs
- History of gastrointestinal bleeding from peptic ulcer disease
- Known psychological problems
- Known skin reaction to patch or bandage adhesives for 8 to 17 year olds
- Known allergies or contraindications to the use of acetylcholinesterase inhibitors
- Prior acetylcholinesterase inhibitor treatment
- Current use of medication for the treatment of ADHD or psychological disorders
- Inability to swallow pills equivalent in size to the 5 mg donepezil tablet
- Females who are pregnant, lactating, or intending to become pregnant within the next 6 months
Where it is running
- Boston Children's Hospital — Boston, Massachusetts, United States
- Boston Children's Hospital at Waltham — Waltham, Massachusetts, United States
- Boston Children's Physicians South — Weymouth, Massachusetts, United States
Full record on ClinicalTrials.gov
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