Complex Dynamic Systems in Mood Disorders
Completed
Conditions studied: Bipolar Disorder, Major Depressive Disorder
In brief
Complex Dynamic Systems in Mood Disorders is an observational, exploratory study of the relationship between voice samples, heart rate, respiration, movement, galvanic skin conductance, and sleep architecture with mood states in patients with Major Depressive Disorder, Bipolar Disorder, and healthy controls. The overall hypothesis is that nonlinear dynamic analyses will be able to reveal hidden patterns of complexity in each domain of voice, heart rate variability, movement, arousal, and sleep stage data.
Key facts
- Study ID
- NCT01583569
- Run by
- Massachusetts General Hospital
- People needed
- 20
- Starts
- 2011-11-01
- Expected to finish
- 2014-12-01
- Last updated by the study team
- 2015-10-07
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age > 18 and < 65.
- Meet DSM-IV criteria for MDD (n=5), BD (n=5), or healthy controls with no psychiatric diagnosis (n=5).
- Willing and able to wear a wearable device to measure sleep parameters
- Willing and able to provide voice samples.
- Subjects with MDD must not be taking psychiatric medications at the time of evaluation.Subjects with BD can be taking psychiatric medications, since it is not feasible for patients with BD to be completely free of mood stabilizing medications. These medications will be limited to lithium, second generation antipsychotics.
- Currently a patient or research participant at the DCRP or the BCRP or are healthy controls enrolled in evaluation studies.
You may not qualify if…
- Primary sleep disorder, including restless legs syndrome, difficulties in initiating and maintaining sleep.
- Movement disorders (e.g. Parkinson's, Huntington's, tardive dyskinesia, primary chorea).
- Active substance abuse or dependence in the past 3 months.
- Cardiovascular or pulmonary disease, including uncontrolled hypertension, arrhythmias, history of myocardial infarction, asthma, COPD, or pulmonary carcinoma.
- Cardiovascular or pulmonary medications (aspirin and statins are allowable).
- Anticonvulsants.
- Sedative/hypnotics (e.g. benzodiazepines, eczopiclone).
- Smokers.
- Pregnancy.
Where it is running
- Bipolar Clinic and Research Program at Massachusetts General Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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