Acoustic Radiation Force Impulse (ARFI) Ultrasound for Noninvasive, Diagnostic Atherosclerosis Imaging
Completed
Conditions studied: Atherosclerosis
In brief
This is a pilot clinical trial to assess the ability of a new ultrasound-based imaging method, Acoustic Radiation Force Impulse (ARFI) ultrasound, to describe the composition and structure of atherosclerotic plaques. The hypothesis being tested is that in vivo, transcutaneous ARFI ultrasound delineates plaque composition and structure in human carotid arteries.
Key facts
- Study ID
- NCT01581385
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 25
- Starts
- 2012-04-01
- Expected to finish
- 2020-05-31
- Last updated by the study team
- 2021-05-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients scheduled to undergo clinically indicated carotid endarterectomy
- Determination of clinical need for carotid endarterectomy will be made by the vascular surgeons on this protocol, but the general criteria include symptomatic carotid disease with a stenosis or lesion in the carotid artery thought to be the source of emboli or asymptomatic carotid artery disease with a > 60% internal carotid artery stenosis in the ipsilateral (surgical) artery.
- Male or Female
- >18 years of age with no upper limit
- Ability to provide informed consent
- Surgeon's approval
- Any ethnicity or race (meeting all other criteria)
You may not qualify if…
- Inability to communicate in English
- Inability to provide valid consent
- Inability to remain motionless for at least 15 minutes
- Carotid arteries deeper than 35 mm
- Pregnancy*
- Pregnant women will be excluded from this study because carotid dissection is more likely than carotid plaque in women of child-bearing age.
Where it is running
- The University of North Carolina at Chapel Hill Hospitals — Chapel Hill, North Carolina, United States
Full record on ClinicalTrials.gov
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