Dynamic Plantar Microvascular Skin Response to Compressive Loads in At-risk Diabetic and Healthy Control: a Pilot Study

Completed

Conditions studied: Foot Ulcer, Diabetic

In brief

The purpose of this pilot study is to compare the dynamic response of microcirculation in the skin on the bottom of the big toe after applying controlled plantar stress in 25 diabetic subjects with a history of foot ulcer and 25 age-matched healthy controls to better understand the role of local hypoxia in neuropathic foot ulceration in subjects with diabetes. The investigators hypothesize that if they apply a gait simulating load to the plantar foot and measure microvascular function, diabetic individuals will demonstrate an increased delay in reestablishing microvascular flow compared to healthy individuals.

Key facts

Study ID

NCT01580917

Run by

Temple University

People needed

18

Starts

2007-11-01

Expected to finish

2015-10-01

Last updated by the study team

2016-12-15

Who can join

Age: 40 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• between ages 40 and 75
• history of diabetic neuropathic plantar ulcer (test subjects)
• no history of diabetes (control subjects)
• no peripheral sensory neuropathy (control subjects)

You may not qualify if…

• amputation or surgery on right Great Toe

Where it is running

• Temple University School of Podiatric Medicine Gait Study Center — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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