The Role of Substance P on Perception of Breathlessness During Resistive Load Breathing

Completed · Not applicable · Has a placebo group

Conditions studied: Chronic Obstructive Pulmonary Disease

In brief

Substance P is released from sensory nerves and transmits pain information into the central nervous system. As pain and dyspnea share many characteristics, including similar neurological pathways, it is possible that substance P may contribute to the sensation of dyspnea. The hypothesis of the study is that patients with chronic obstructive pulmonary disease (COPD) will provide lower ratings of breathlessness during resistive load breathing with oral aprepitant, a medication that blocks the activity of substance P, compared with placebo.

Key facts

Study ID

NCT01580423

Run by

Dartmouth-Hitchcock Medical Center

People needed

16

Starts

2012-04-01

Expected to finish

2013-03-01

Last updated by the study team

2013-07-19

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 50 years of age or older
• diagnosis of COPD
• former smoker > 10 pack-years
• clinical diagnosis of chronic bronchitis
• post-bronchodilator forced expiratory volume in one second (FEV1) 30 - 80% predicted
• FEV1/forced vital capacity ratio less than or equal to 70%

You may not qualify if…

• current smoker
• pregnant women
• concomitant disease that might interfere with study procedures
• peripheral vascular disease or cold hypersensitivity
• drugs that might interfere with aprepitant

Where it is running

• Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States

Full record on ClinicalTrials.gov

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