Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of the Appendix

Completed · Phase 2

Conditions studied: Carcinoma of the Appendix, Primary Peritoneal Cavity Cancer

In brief

This randomized phase II trial is studying the side effects and how well giving oxaliplatin or mitomycin C directly into the abdomen after surgery works in treating patients with tumors of the appendix. Drugs used in chemotherapy, such as oxaliplatin and mitomycin C, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Heating a chemotherapy solution and infusing it directly into the abdomen may kill more tumor cells. Giving these treatments after surgery may kill any tumor cells that remain after surgery.

Key facts

Study ID: NCT01580410
Run by: Wake Forest University Health Sciences
People needed: 136
Starts: 2009-05-01
Expected to finish: 2016-11-01
Last updated by the study team: 2018-07-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients must have histologically or cytologically confirmed peritoneal surface malignancies from primary appendiceal tumors
Eastern Cooperative Oncology Group (ECOG) performance status =< 2
Absolute neutrophil count >= 1,500/mcL
Platelets >=100,000/mcL
Total bilirubin =< 1.5 mg/dL
Creatinine =< 2.0 mg/dL
Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]) =< 3 X institutional upper limit of normal
Alkaline phosphatase =< 3 X institutional upper limit of normal
Patients must be recovered from both the acute and late effects of any prior surgery, radiotherapy, or other antineoplastic therapy
Women of child-bearing potential and men must agree to use adequate contraception (hormonal or double-barrier method of birth control; abstinence) for the duration of study participation and for 90 days following HIPEC
Ability to understand and the willingness to sign a written informed consent document (either directly or via a legally authorized representative)
Participants who have received oxaliplatin during prior systemic chemotherapy regimens are eligible for enrollment in this protocol

You may not qualify if…

Patients with an active infection or with a fever >= 101.3 degrees Fahrenheit (F) within 3 days of the first scheduled day of protocol treatment
Patients who are receiving concurrent investigational therapy or who have received investigational therapy within 30 days of HIPEC (investigational therapy is defined as treatment for which there is currently no regulatory authority approved indication)
Patients with carcinoid tumors
Patients with active central nervous system (CNS) metastases
Patients with known hypersensitivity to any of the components of oxaliplatin or mitomycin C
History of prior malignancy within the past 5 years, except for curatively treated basal cell carcinoma of the skin, cervical intra-epithelial neoplasia, or localized prostate cancer with a current prostate-specific antigen (PSA) of < 1.0 mg/dL on 2 successive evaluations, at least 3 months apart, with the most recent evaluation no more than 4 weeks prior to entry
Patients who received radiotherapy to more than 25% of their bone marrow
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
Pregnant/nursing women are excluded from this study because oxaliplatin is an agent with the potential for teratogenic or abortifacient effects; because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with oxaliplatin, breastfeeding should be discontinued if the mother is treated with oxaliplatin or mitomycin C
Known human immunodeficiency virus (HIV), hepatitis B or C-positive patients (active, previously treated or both)
Peripheral neuropathy >= grade 2
History of allogenic transplant
History of prior HIPEC
Evidence of metastatic disease outside of the abdomen

Where it is running

Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States
UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania, United States
M D Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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