Buprenorphine Disposition and CYP3A

Completed · Not applicable

Conditions studied: Healthy

In brief

To evaluate role of CYP3A in buprenorphine disposition and effect

Key facts

Study ID

NCT01576575

Run by

Washington University School of Medicine

People needed

21

Starts

2010-06-01

Expected to finish

2014-03-29

Last updated by the study team

2020-01-22

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Each subject must meet all of the following criteria:
• Male or non-pregnant female volunteer, 18-50 yr old
• Good general health with no known major medical conditions
• BMI < 33
• Provide informed consent

You may not qualify if…

• Subjects will not be enrolled if any of the following criteria exist:
• Known history of liver or kidney disease
• Use of prescription or non-prescription medications, herbals or foods known to be metabolized by or affect CYP3A activity (this includes the use of oral contraceptives).
• Females who are pregnant or nursing
• Known history of drug or alcohol addiction (prior or present addiction or addiction treatment)
• Direct physical access to and routine handling of addicting drugs in the regular course of duty (this is a routine exclusion from studies of drugs with addiction potential)

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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