Pilot Study: Dynamic Contrast-enhanced Magnetic Resonance Imaging(DCE-MRI)for Assessing Tumor Vascularity and Permeability in Soft Tissue Sarcoma Treated With Preoperative Radiotherapy Followed by Surgical Resection
Completed · Not applicable
Conditions studied: Soft Tissue Sarcoma
In brief
This is a pilot study to determine the diagnostic value of dynamic contrast enhancing MRI (DCE-MRI) in soft tissue sarcoma for assessment of tumor radiographic changes in vascular permeability and microvessel density before and after preoperative radiotherapy.
Key facts
- Study ID
- NCT01575951
- Run by
- University of Utah
- People needed
- 16
- Starts
- 2010-02-01
- Expected to finish
- 2014-12-05
- Last updated by the study team
- 2020-04-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Pathologically confirmed soft tissue sarcoma.
- Age ≥ 18.
- ECOG 0-1.
- Able to receive preoperative radiotherapy followed by surgical resection.
- Able to provide treatment consent forms that conforms to federal and institutional guidelines.
- Have adequate kidney function for safe administration of gadolinium contrast, as determined by current Department of Radiology MRI guidelines.
- Creatinine clearance either by 24 hour collection or nomogram:
- Creatinine clearance (CC) > 50 ml/min is determined by 24 hour collection or nomogram: CC male = (140 - age) x (wt. in kg)/(Serum Cr mg/dl) x 72 CC female = 0.85 x (CC male)
You may not qualify if…
- Patients have claustrophobia, iron or metal in the MRI scan site or pacemaker which are contraindicated for MRI scan.
- patients have pacemaker or defibrillator and contraindicated to MRI images
- Patients are allergic to gadolinium IV contrast.
- Patients have acute or chronic renal insufficiency and contraindicated to gadolinium contrast enhancing MRI.
- Patient had previous radiation to the same disease site.
- Patient had chemotherapy prior to preoperative radiotherapy.
- Patients that are pregnant. Patients that may become pregnant must have a negative pregnancy test prior to enrolling.
Where it is running
- Huntsman Cancer Institute — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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