Movement Velocity Effect on Cortical Reorganization and Finger Function in Stroke

Completed · Phase 1

Conditions studied: Stroke

In brief

Aim 1. Determine whether higher-velocity finger tracking training improves hand function more than slower velocity training. Working hypotheses: The higher-velocity training will have significantly greater functional improvement compared to the lower-velocity training, as measured by standardized upper extremity functional tests (Jebsen Taylor test, Box \& Block Test, and Finger extension force test) Aim 2. Ascertain whether higher-velocity finger tracking training differentially induces cortical reorganization as compared to lower-velocity finger tracking training. Working hypotheses: The higher-velocity training will have significantly greater cortical reorganization compared to the lower-velocity training, as measured by: 1. TMS - increased amplitude of motor evoked potentials (MEP) from paretic extensor digitorum muscle in response to paired-pulse TMS to ipsilesional primary motor area (M1). 2. fMRI - increased volume of activation, signal intensity, and laterality of ipsilesional M1. Aim 3. Explore whether the functional improvements correlate with the cortical reorganization. Working hypotheses: The functional improvements will correlate with the cortical reorganization.

Key facts

Study ID
NCT01575366
Run by
University of Minnesota
People needed
5
Starts
2010-02-01
Expected to finish
2012-08-01
Last updated by the study team
2019-11-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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