Effects of rTMS and tDCS on Motor Function in Stroke
Completed · Not applicable · Has a placebo group
Conditions studied: Stroke, Motor Function
In brief
In this study the investigators aim to investigate the effects of two different types of non-invasive brain stimulation techniques -- repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) on motor function in stroke. This is a cross-over study where subjects will receive 5 sessions of stimulation (each separated by 1 week) -- with either active tDCS and sham rTMS, sham tDCS and active rTMS or both sham tDCS and rTMS.
Key facts
- Study ID
- NCT01574989
- Run by
- Spaulding Rehabilitation Hospital
- People needed
- 14
- Starts
- 2011-05-01
- Expected to finish
- 2014-11-01
- Last updated by the study team
- 2020-04-24
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- (1) All subjects must be between the ages of 18-90.
You may not qualify if…
- History of Major depression, as defined by Beck Depression scale 30;
- Any substantial decrease in alertness, language comprehension, or attention that might interfere with understanding instructions for motor testing;
- Contraindications to TMS
- history of seizures
- unexplained loss of consciousness
- metal in the head
- frequent or severe headaches or neck pain
- implanted brain medical devices.
- Contraindications to tDCS
- metal in the head
- implanted brain medical devices
- Advanced liver, kidney, cardiac, or pulmonary disease;
- A terminal medical diagnosis consistent with survival < 1 year;
- Coexistent major neurological or psychiatric disease (to decrease number of confounders);
- A history of significant alcohol or drug abuse in the prior 6 months;
- Subjects may not be actively enrolled in a separate intervention study targeting stroke recovery and any other clinical trials;
- Subjects with global aphasia and deficits of comprehension
- Pregnancy. Female subjects of child bearing potential will be asked to take a pregnancy test. If the pregnancy test is positive, the subject may not enroll in the study.
- Use of neuropsychotropic medications [healthy subjects only]
- Additional inclusion criteria for stroke subjects:
- First-time clinical ischemic or hemorrhagic cerebrovascular events - evidenced by a radiological (or physician's) report
- Weakness, defined as score of less than 55 (out of 66) on arm motor Fugl-Meyer (FM) scale
- Stroke onset >6 months prior to study enrollment .
- Additional exclusion criteria for stroke subjects:
- Subjects may not have already received TMS and/or tDCS stimulation for stroke;
Where it is running
- Spaulding Rehabilitation Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.