The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections

Completed · Phase 4

Conditions studied: Pain

In brief

The inferior alveolar nerve block (shot) is the most frequently used injection technique for achieving local anesthesia (numbness) for the teeth in the lower jaw. However, this injection does not always result in successful pulpal (tooth) anesthesia (patient felt pain). No study has combined mepivacaine and lidocaine anesthetics (numbing solutions) for this type of injection (shot). The investigators propose to compare an injection of mepivacaine followed by lidocaine to an injection of lidocaine followed by lidocaine to determine if there is a difference in effectiveness.

Key facts

Study ID

NCT01574807

Run by

Ohio State University

People needed

100

Starts

2012-05-01

Expected to finish

2013-05-01

Last updated by the study team

2020-11-17

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• between the ages of 18 and 65 years
• good health (ASA classification I or II)
• able to provide informed consent

You may not qualify if…

• allergy to lidocaine or mepivacaine
• history of significant medical problem (ASA classification III or greater)
• depression
• have taken CNS depressants (including alcohol or any analgesic medications) within the last 48 hours
• lactating or pregnant
• inability to give informed consent

Where it is running

• The Ohio State University College of Dentistry, Postle Hall — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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