Impact of Weight Loss on Gastroesophageal Reflux Disease in Overweight and Obese Subjects: a Prospective Study

Stopped early · Not applicable

Conditions studied: GERD, Obesity

In brief

By affecting the gastroesophageal pressure gradient, obesity predisposes to reflux of gastric contents. The investigators hypothesized that the loss of weight will decrease this gradient and as a result decrease the severity and frequency of GERD symptoms. GERD negatively affects health related quality of life. Since loss of weight may decrease gastroesophageal reflux, the investigators hypothesized that it obesity contributes to poor quality of life in GERD subjects and losing weight should also favorably impact and improve quality of life in GERD patients.

Key facts

Study ID

NCT01574573

Run by

Midwest Biomedical Research

People needed

52

Starts

2009-06-01

Expected to finish

2017-05-01

Last updated by the study team

2018-01-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Must be a Kansas City Veterans Hospital patient who is enrolled in the MOVE weight loss program
• Patients with a BMI > 25 with associated co-morbid medical conditions such as diabetes, high blood pressure, high cholesterol, arthritis, heart disease, low back pain, sleep apnea, or other obesity associated condition.
• Enrollment in MOVE program is optional for patients with a BMI > 25 with no co-morbid medical conditions.
• Enrollment for patients 70 years or older with BMI > 25 is optional and requires mandatory medical clearance prior to beginning new physical activity and closer nutritional supervision to minimize protein, vitamin and mineral deficiencies.

You may not qualify if…

• Active cancer other than non-melanoma skin cancer
• End stage COPD, congestive heart failure
• End stage neurologic disorder (Parkinson's, ALS, MS)
• Long-term care facility resident
• End stage renal disease
• Moderate to severe cognitive impairment (dementia, post-stroke)
• Active psychosis or substance abuse
• AIDS (except asymptomatic HIV infection)

Where it is running

• Topeka VA Medical Center — Topeka, Kansas, United States
• Kansas City VA Medical Center — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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