Brain Dynamics in Different Stages of Arousal and Anesthesia

Stopped early

Conditions studied: Epilepsy

In brief

The principle aim of this project is to characterize the changes in relative stability of the intrinsic brain dynamics during onset of sleep and induction of general anesthesia. The investigators hypothesize that brain dynamics in the awake state are critical akin to physical systems close to a second order phase transition and that during loss of consciousness the dynamics move away from the critical point.

Key facts

Study ID

NCT01574443

Run by

Weill Medical College of Cornell University

People needed

5

Starts

2011-08-22

Expected to finish

2016-04-08

Last updated by the study team

2017-11-06

Who can join

Age: 15 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients referred for epilepsy resection surgery with Dr. Theodore Schwartz

You may not qualify if…

• Patient refusal.
• Patients requiring rapid sequence induction because of concerns about delayed gastric emptying as a result of diabetes or other medical conditions.
• Age less than 15 or greater than 65 years old.
• Pregnant or nursing.
• Inability to follow simple commands such as "Open your eyes" and "Squeeze my hand" for any reason.
• Severe mental disability.
• Allergy to propofol or any components of the formulation.
• Poor suitability for propofol infusion because of other medical concerns such as severe heart disease.
• Patients deemed to have a difficult airway thus necessitating awake fiberoptic intubation.
• Patients with severe sleep apnea requiring CPAP/BiPAP.

Where it is running

• New York Presbyterian Hospital/ Weill Cornell Medical College — New York, New York, United States

Full record on ClinicalTrials.gov

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