Effect of Bradykinin Receptor Antagonism on ACE Inhibitor-associated Angioedema

Stopped early · Phase 4 · Has a placebo group

Conditions studied: ACE Inhibitor-associated Angioedema

In brief

Individuals with heart disease or high blood pressure are often prescribed angiotensin converting enzyme (ACE) inhibitors to treat their disease. However, the use of ACE inhibitors can be associated with angioedema, a rare but life-threatening condition that causes swelling of the face and other body parts. This study will evaluate the effectiveness of the drug HOE-140 at decreasing symptoms of angioedema in people taking ACE inhibitors who develop the condition.

Key facts

Study ID

NCT01574248

Run by

Vanderbilt University Medical Center

People needed

33

Starts

2011-08-01

Expected to finish

2016-02-01

Last updated by the study team

2017-02-17

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The subject has ongoing angioedema while taking an ACE inhibitor.
• The subject is between 18 and 80 years of age.

You may not qualify if…

• The subject has had angioedema while not taking an ACE inhibitor.
• The subject's angioedema only involves the bowel.
• The subject is known to be pregnant or has a positive urine pregnancy test.
• The subject has started on an oral contraceptive within the last 6 months.

Where it is running

• University of California, San Diego — San Diego, California, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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