European Multicentre Study of Human Spinal Cord Injury

Recruiting now

Conditions studied: Spinal Cord Injury

In brief

Today there is accumulating evidence from animal experiments that regeneration can be induced after a spinal cord injury (SCI). Consequently in the near future, new therapeutic approaches to induce some regeneration will be included in the treatment of patients with SCI. The aim of this proposal is to provide the required clinical basis for the implementation of novel interventional therapies. The establishment of combined clinical, functional and neurophysiological measures for a qualitative and quantitative assessment of spinal cord function in patients with SCI at different stages during rehabilitation represents a basic requirement to monitor any significant effect of a new treatment. Therefore, several European Paraplegic Centres involved in the rehabilitation of acute traumatic SCI patients build up a close collaboration for standardised assessment. The aim is to get knowledge about the natural recovery after spinal cord lesion in a larger population of patients in the sense of a historical control group and to bring new standardised assessment tools to the clinical setting.

Key facts

Study ID

NCT01571531

Run by

University of Zurich

People needed

8000

Starts

2004-04-01

Expected to finish

2026-08-01

Last updated by the study team

2025-12-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Single event traumatic or ischemic para- or tetraplegia
• First EMSCI assessment possible within the first 6 weeks after incidence
• Patient capable and willing of giving written informed consent

You may not qualify if…

• Nontraumatic para- or tetraplegia (i.e. discusprolaps, tumor, AV-malformation, myelitis) excl. single event ischemic incidences
• Pre-known dementia or severe reduction of intelligence, leading to reduced capabilities of cooperation or giving consent
• Peripheral nerve lesions above the level of lesion (i.e. plexus brachialis impairment)
• Pre-known polyneuropathy
• Severe craniocerebral injury

Where it is running

• University of Zurich — Zurich, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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