Clinical Trials to Reduce the Risk of Antimicrobial Resistance

Stopped early · Phase 2

Conditions studied: Bacterial Pneumonia

In brief

The primary objective of this study is to demonstrate a low rate of emergence of antibiotic resistance in P. aeruginosa and Acinetobacter spp during the treatment of hospitalized patients with pneumonia requiring mechanical ventilation treated with PD optimized meropenem administered as a prolonged infusion in combination with a parenteral aminoglycoside plus tobramycin by inhalation (Group 1) compared to therapy with meropenem alone (Group 2 - control arm).

Key facts

Study ID

NCT01570192

Run by

University of Florida

People needed

43

Starts

2010-09-01

Expected to finish

2015-04-01

Last updated by the study team

2017-09-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Written informed consent by the subject/subject's LAR.
• Hospitalized males or females ≥ 18 yrs with respiratory failure requiring mechanical ventilation and clinical suspicion of HABP, HCAP or VABP.
• Onset or exacerbation of pneumonia at least 48 hours after admission to any patient health care facility or onset of pneumonia in a nursing home or rehabilitation facility with subsequent transfer to an acute care facility
• Women of childbearing potential if their pregnancy test is negative
• Subjects who have received previous antibacterial therapy within 14 days of pre-treatment bronchoscopy entry may be entered only if the subject has not responded clinically.). While less than 24 hours of pre-treatment antibiotics is preferential, recovery of >104 CFU/ml in the quantitative Bronchoscopic BAL will be seen as primary evidence that the prior therapy was not efficacious and enrollment will be allowed.)
• Patients should have clinical findings that support a diagnosis of HABP/VABP/HCAP:
• Within 48 hours before starting empiric therapy a subject's chest radiograph should show the presence of a NEW or progressive infiltrate, cavitation, or effusion suggestive of pneumonia
• Within 36 hours before the start of empiric study therapy, a quantitative culture of Bronchoscopic BAL fluid must be obtained.
• Patients with VABP should have a Clinical Pulmonary Infection Score of >/= 5.

You may not qualify if…

• Subjects with pneumonia caused by pathogens resistant to meropenem (MIC greater than or equal to 16µg/ml) or a prior meropenem therapy failure.
• Subjects with contra-indications to ANY study medication, in particular with known or suspected allergy or hypersensitivity.
• Women who are pregnant or lactating.
• Subjects taking anticonvulsant medications for a known seizure disorder.Patients with a history of seizures, AND who are stabilized on anti-seizure medication, may be enrolled into the study at the discretion of the site investigator.
• Subjects with known or suspected community acquired bacterial pneumonia (CABP) or viral pneumonia; or Subjects with acute exacerbation of chronic bronchitis without evidence of pneumonia.
• Subjects with primary lung cancer or another malignancy metastatic to the lungs.
• Subjects who were previously enrolled in this study.
• Subjects who have had an investigational drug or have used an investigational device within 30 days prior to entering the study.
• Subjects with another focus of infection requiring concurrent antibiotics that would interfere with evaluation of the response to study drug.
• Subjects with cystic fibrosis, AIDS with a CD4 lymphocyte count <200 cells/µl, neutropenia (absolute neutrophil count <500 cells/ml), known or suspected active tuberculosis.
• Subjects with little chance of survival for the duration of study therapy.
• Subjects with an APACHE II score >35.
• Subjects with underlying condition(s) which would make it difficult to interpret response to the study drugs.
• Subjects with hypotension or acidosis despite attempts at fluid resuscitation. Subjects requiring ongoing treatment with vasopressors will be eligible for the study if their hypotension is controlled and acidosis has resolved. Subjects with intractable septic shock are not eligible for enrollment.
• Subjects who have undergone bone marrow transplantation.
• Subjects with profound hypoxia as defined by a PaO2/FiO2 ratio <100.

Where it is running

• InClin, Inc. — San Mateo, California, United States
• UFL Department of Medicine: Pulmonary, Critical Care and Sleep Medicine — Gainesville, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Northwestern University — Chicago, Illinois, United States
• JMI Laboratories — North Liberty, Iowa, United States
• Washington University in St. Louis School of Medicine — St Louis, Missouri, United States
• Weill Cornell Medical Center of Cornell University — New York, New York, United States
• Cleveland Clinic Lerner College of Medicine — Cleveland, Ohio, United States
• Institut de Cardiologie, Groupe Hospitalier Pitie-Salpetriere — Paris, France
• Hannover Clinical Trial Center GmbH — Hanover, Germany
• Hospital Vall d'Hebron — Barcelona, Spain

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.