Structurally Reorganizing Motor Cortex in Stroke Patients Through Hebbian-type Stimulation
Completed · Not applicable · Has a placebo group
Conditions studied: Stroke
In brief
Stroke is a leading cause of morbidity in the United States but identification of treatment strategies to improve outcome is limited by the incomplete understanding of the mechanisms of recovery. Motor cortex (M1) reorganization plays a major-role in the recovery of motor deficits post-stroke; hence the importance for further development of rehabilitative strategies that utilize this potential for recovery. In Specific Aim 1, investigators will determine if repeated exposure to training combined with Hebbian-type M1 stimulation enhances functional M1 reorganization in lesioned M1 of stroke patients. In Specific Aim 2, investigators will determine if repeated exposure to training combined with Hebbian-type M1 stimulation enhances structural cortical reorganization in lesioned M1 of stroke patients and to explore whether these structural changes are related to the training induced functional cortical reorganization. The overall goal of this project is to determine the effect of Hebbian- type stimulation on both, functional and structural brain reorganization, thereby obtaining indirect evidence for the neuronal substrate underlying training related improvement and maintenance of motor function in stroke patients. This knowledge may have a substantial positive impact on treatment for stroke patients that may significantly improve recovery and could move the field of neuro-rehabilitation forward.
Key facts
- Study ID
- NCT01569607
- Run by
- Cathrin Buetefisch
- People needed
- 48
- Starts
- 2012-03-08
- Expected to finish
- 2016-08-26
- Last updated by the study team
- 2018-01-16
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-85
- Single cerebral ischemic infarction > 6 month affecting the primary motor output system of the hand at a cortical (M1) level as defined by MRI of the brain
- At the time of cerebral infarct a motor deficit of hand of MRC of <4- of wrist and finger extension/flexion movement
- Good recovery of hand function as defined by MRC of 4 or 4+ of wrist- and finger extension/flexion movements
- Ability to perform wrist extension movements
- No other neurological disorder
- No intake of CNS active drugs
- Ability to give informed consent
- Ability to meet criteria of inclusion experiment
- No major cognitive impairment
- No contraindication to TMS or MRI
Where it is running
- Emory University School of Medicine — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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