Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Completed · Phase 4
Conditions studied: Anesthetic Effectiveness
In brief
Infiltration (injecting next to the tooth) injections are common in dentistry and a number of studies have shown that articaine anesthetic, when injected next to the tooth as a supplemental injection, works very well following a typical inferior alveolar (lower jaw) nerve block. No study has compared 4% articaine with 1:100,000 epinephrine, 4% prilocaine with 1:200,000 epinephrine, and 4% lidocaine with 1:100,000 epinephrine in mandibular (lower jaw) infiltration injections of the first molar. The purpose of this prospective, randomized, double-blind, crossover study is to compare the degree of anesthesia obtained from the three solutions as a primary infiltration injection next to the mandibular first molar. The investigators also will record the pain of injection and postoperative pain.
Key facts
- Study ID
- NCT01567839
- Run by
- Ohio State University
- People needed
- 60
- Starts
- 2012-05-01
- Expected to finish
- 2013-05-01
- Last updated by the study team
- 2014-01-01
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- between the ages of 18 and 65 years.
- in good health (ASA classification II or lower).
- able to provide informed consent.
You may not qualify if…
- allergy to articaine, lidocaine or prilocaine.
- history of significant medical problems (ASA classification III or greater).
- depression (taking tri-cyclic antidepressant medications to control).
- have taken CNS depressants (including alcohol or any analgesic medications) within the last 48 hours prior to testing.
- lactating or pregnant.
- inability to give informed consent.
Where it is running
- The Ohio State University College of Dentistry, Postle Hall — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.