Biological Basis of Individual Variation in Social Cooperation
Completed · Not applicable · Has a placebo group
Conditions studied: Healthy
In brief
The project has three overall objectives. The first is to determine whether and how administration of intranasal oxytocin (OT) and intranasal vasopressin (AVP) influence cooperative decision-making and neural responses to cooperative and un-cooperative social interactions. The second is to determine whether and how intranasal vasopressin influences subjective evaluations of and neural responses to same and opposite-sex face stimuli and to determine if any of these effects persist beyond the period of AVP exposure. The third objective is to determine if intranasal OT influences empathy-related behavior and associated brain activity.
Key facts
- Study ID
- NCT01566539
- Run by
- Emory University
- People needed
- 707
- Starts
- 2008-04-01
- Expected to finish
- 2016-11-01
- Last updated by the study team
- 2017-09-25
Who can join
Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 18-30 years of age
- 21-30 for Faces component
- Normal or corrected-to-normal vision of 20/40
- Unmedicated depressed or anxious men between 18-22 years of age for Anxious and Depressed component
You may not qualify if…
- Pregnancy, recent birth, or breastfeeding
- History of seizures
- Neurological Disorder
- Current psychiatric disorder
- Previous psychiatric disorder (can be included as discretion of PI)
- Current use of psychoactive drugs
- Previous use of psychoactive drugs (can be included as discretion of PI)
- Previous head trauma (can be included at discretion of PI)
- Alcoholism or substance abuse
- Hypertension
- Cardiovascular Disease
- Nephritis
- Diabetes
- Endocrine disease or malignancy
- Asthma (can be included as discretion of PI, if episodes are infrequent, nonmedicated, and no active problems at time of study)
- Migraines (can be included as discretion of PI, if episodes are infrequent, nonmedicated, and no active problems at time of study)
- Claustrophobia (at discretion of PI)
- Additional exclusion criteria for Lorazepam arm
- Acute narrow-angle glaucoma
- Compromised respiratory function (e.g. sleep apnea and chronic obstructive pulmonary disease)
- Impaired renal and hepatic function
Where it is running
- Emory University Hospital — Atlanta, Georgia, United States
- Emory University 1462 Clifton Rd — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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