Efficacy of Dietary Sodium Restriction of Improving Vascular Endothelial Function in Middle Aged and Older Adults

Completed · Not applicable · Has a placebo group

Conditions studied: Hypertension

In brief

The investigators hypothesize that reducing salt in the diet will improve the function of blood vessels in middle aged and older adults with moderately elevated systolic blood pressure, by increasing the amount of BH4 and nitric oxide in your blood vessels and reducing the amount of oxidative stress.

Key facts

Study ID

NCT01566084

Run by

University of Colorado, Boulder

People needed

17

Starts

2009-02-01

Expected to finish

2012-01-01

Last updated by the study team

2016-01-07

Who can join

Age: 50 and older, up to 79. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 50-79 years of age
• SBP 130-159 mmHg

You may not qualify if…

• Have been sick with an infection in the past two weeks
• Are currently sick or have ongoing health problems such as kidney or CVD
• Have lost more than 11 lbs. in the last 3 months
• Are taking any type of antioxidants
• Smoke or have alcohol problems
• Have blood glucose levels higher than 126 mg/dL
• Have resting SBP below or less than 100 mmHg or greater than 159 mmHg
• Have a resting diastolic blood pressure greater than 99 mmHg
• Have a BMI greater than 40 kg/m\^2
• Are presently consuming less than 9 or greater than 18 grams of salt / day
• Have a baseline FMD of greater than 6%
• Are taking any of the following types of drugs: blood thinners, anti-seizure medications, ant-inflammatory drugs
• Participate in any high endurance athletic training
• Taking Hormone Replacement Therapy
• Have not been post-menopausal for at least 1 year

Where it is running

• Clinical Translational Research Center — Boulder, Colorado, United States

Full record on ClinicalTrials.gov

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