A Phase 2 Evaluation of TRC105 In Combination With Bevacizumab in Patients With Glioblastoma
Completed · Phase 2
Conditions studied: Glioblastoma, Glioblastoma Multiforme
In brief
The purpose of this study is to evaluate the safety and efficacy of TRC105 in patients with recurrent or progressive glioblastoma after prior antiangiogenic therapy (including anti-VEGF therapy)
Key facts
- Study ID
- NCT01564914
- Run by
- Tracon Pharmaceuticals Inc.
- People needed
- 22
- Starts
- 2012-05-01
- Expected to finish
- 2015-06-01
- Last updated by the study team
- 2019-06-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with histologically confirmed glioblastoma, recurrent after prior external-beam fractionated radiotherapy and temozolomide chemotherapy.
- Patients with documented radiographic progression following bevacizumab therapy for treatment of glioblastoma.
- Patients with up to 3 prior recurrences are allowed.
- Karnofsky performance status ≥ 70%.
- Age ≥ 18 years old.
- Normal organ function
You may not qualify if…
- Patients who have had previous treatment with TRC105.
- Patients who have undergone major surgery (e.g. intra-thoracic, intra-abdominal or intra-pelvic), open biopsy or significant traumatic injury ≤ 4 weeks prior to starting study drug, or patients who have had minor procedures, percutaneous biopsies or placement of vascular access device ≤ 1 week prior to starting study drug, or who have not recovered from side effects of such procedure or injury
- Patients with cirrhosis, or active viral or nonviral hepatitis.
- Patients with active bleeding or pathologic conditions that carry a high risk of bleeding,(i.e. hereditary hemorrhagic telangiectasia).
- Patients who are currently receiving anticoagulation treatment
- Patients unwilling or unable to comply with the protocol
Where it is running
- University of Cincinnati — Cincinnati, Ohio, United States
- University Hospitals of Cleveland — Cleveland, Ohio, United States
- Cleveland Clinic — Cleveland, Ohio, United States
- Ohio State University — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.