Effect of Sodium Intake on Calcium Retention in Girls
Completed · Not applicable
Conditions studied: Osteoporosis
In brief
Optimal calcium retention is important for building bone mass within the genetic potential, a key to reducing risk of osteoporosis later in life. Calcium retention is high during the rapid growth period. The investigators know that urinary calcium is affected by sodium intake but the investigators do not know the effects of sodium intake during the growth spurt or the differences in calcium retention between blacks and whites. Our hypothesis was that a high dietary sodium increases the calcium intakes required for optimal calcium retention in both black and white adolescent girls. The investigators tested calcium retention while girls consumed a low and high sodium diet during three week periods. The subjects were housed in a Purdue fraternity house during the summer and they were supervised at all times by trained staff. During the summer of 1999, subjects consumed diets with 2 levels of dietary Na+ with a fixed diet low in calcium. On the next summer, they switched to a high calcium diet. Subjects collected fecal and urine daily for 20 days. Other measurements included daily body weight, blood pressure every other day, blood sample at the end of each session. Baseline measures included bone mass, self-assessment of pubertal development, a physical examination and diet history.
Key facts
- Study ID
- NCT01564238
- Run by
- Purdue University
- People needed
- 67
- Starts
- 1999-01-01
- Expected to finish
- 2000-08-01
- Last updated by the study team
- 2018-05-09
Who can join
Age: 11 and older, up to 15. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- White or black race (both parents and grandparents had to be white or black to be eligible in the study).
You may not qualify if…
- < 11 or > 15 years
- body mass index (BMI) of < 15th or > 85th percentile for age
- history of amenorrhea, pregnancy or abortion, eating disorders, oral contraceptive or tobacco use.
Where it is running
- Purdue University — West Lafayette, Indiana, United States
Full record on ClinicalTrials.gov
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