Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride
Completed · Phase 4
Conditions studied: Dental Caries
In brief
This study will evaluate and compare the effect of the amount of toothpaste used and brushing time on enamel strengthening (percent of surface microhardness recovery, % SMHR) and enamel fluoride uptake (EFU).
Key facts
- Study ID
- NCT01563172
- Run by
- GlaxoSmithKline
- People needed
- 65
- Starts
- 2009-01-01
- Expected to finish
- 2009-06-01
- Last updated by the study team
- 2018-02-07
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- General and Dental Health
- Good general and dental health with (in the opinion of the investigator) no clinically significant and relevant abnormalities of medical history or oral examination
- Have no current active caries or periodontal disease that may compromise the study or the health of the subjects
- Residency: Currently living in the Indianapolis, Indiana area
- Dentures:
- Currently wearing a removable mandibular partial denture with sufficient room in the posterior buccal flange area to accommodate two enamel specimens (required dimensions 12 mm x 7 mm)
- Willing to have their denture modified to accommodate enamel test specimens and willing and capable of wearing their removable mandibular partial dentures 24 hours per day during the experimental periods
- All restorations in a good state of repair
- Salivary Flow: Have a salivary flow rate in the range of normal values (unstimulated whole saliva flow rate ≥ 0.2 mL/minute; gum base stimulated whole saliva flow rate ≥ 0.8 mL/minute)
You may not qualify if…
- Antibiotics: Use of antibiotics two weeks prior to a treatment visit or anticipated use during the study treatment periods
- Study Scale Use: Subjects unable to measure product weights accurately using the assigned study scale as determined by the study staff (as demonstrated on or before Visit 4)
- A member of the site study staff who is directly working on the project or living in that staff's household
- Any employee of any toothpaste manufacturer or their spouse or family member
Where it is running
- Indiana University School of Dentistry — Indianapolis, Indiana, United States
Full record on ClinicalTrials.gov
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