The ParkCycle Study: Aerobic Exercise in PD
Completed · Not applicable
Conditions studied: Parkinson's Disease
In brief
The primary goal of this study is to determine the neuroprotective qualities of long-term, in home, exercise therapy program in human PD patients. It is hypothesized that an exercise intervention might delay the onset of levo-dopa therapy (i.e. evidence for neuroprotection). The first part involves a pilot-study in which the feasibility of the intervention and outcome measures will be tested.
Key facts
- Study ID
- NCT01562496
- Run by
- Radboud University Medical Center
- People needed
- 35
- Starts
- 2012-01-01
- Expected to finish
- 2014-10-01
- Last updated by the study team
- 2014-11-13
Who can join
Age: 30 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of idiopathic Parkinson's disease according to the UK Queen Square Brain Bank Criteria
- Hoehn \& Yahr disease stages I-II
- Age between 30 and 75 years
- Having insufficient physical activity according to the ACSM guideline for adults, 50-64 years old with a chronic condition
- Untreated with anti-parkinsonian medication or receiving medication, for less than two years, medication-responsive without fluctuations.
You may not qualify if…
- Unclear diagnosis with Red Flags
- Advanced problems in cognitive functioning: Mini Mental State Examination (MMSE)19 score < 24
- Serious co-morbidity: neurological or orthopedic disorder that severely affects movement; known by specialist or medical practitioner
- Pulmonary diseases; known by specialist or medical practitioner
- Stroke
- High risk of cardiovascular complications:
- Hypertension (systole >150 and diastole > 100)
- Diabetes Mellitus; known by specialist or medical practitioner
- Cardiac valve defect (especially aortic valve stenosis); known by specialist or medical practitioner
- Cardiac rhythm disorder; known by specialist or medical practitioner
- Heart failure; known by specialist or medical practitioner
- Use of ß-blockers
- Not able to complete American (for Cleveland site) or Dutch questionnaires (for the Nijmegen site)
- Daily institutionalized care
- Contra-indications for fMRI:
- Pregnancy
- Metallic implants or electronic devices
- Previous seizure
- Claustrophobia
- Not able to keep the head still for longer period, i.e. due to severe head tremor
Where it is running
- Cleveland clinic — Cleveland, Ohio, United States
- UMC St Radboud — Nijmegen, Netherlands
Full record on ClinicalTrials.gov
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