Hypothermia's Impact on Pharmacology
Completed
Conditions studied: Cardiac Arrest, Hypothermia
In brief
The purpose of the study will help us understand the complex interaction between hypothermia (cooling) and pharmacogenetics (how specific genes effect how drugs are handled), and their impact on how routinely given sedation drug are broken down and used by the body when given to children after cardiac arrest (when heart stops pumping blood) and are critically ill.
Key facts
- Study ID
- NCT01560338
- Run by
- Children's Hospital of Philadelphia
- People needed
- 41
- Starts
- 2012-03-01
- Expected to finish
- 2018-01-28
- Last updated by the study team
- 2021-03-02
Who can join
Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Be greater than or equal to three (3) kg
- Receiving or have received morphine and/or midazolam as part of clinical care
- Receiving hypothermia after any cardiac arrest
- Provide Informed Consent
You may not qualify if…
- Receiving renal replacement therapy [example Continuous Veno-Venous Hemofiltration (CVVH), Continuous Veno-Venous Hemodialysis (CVVHD), and Continuous Veno-Venous Hemodiafiltration (CVVHDF)]
- Receiving plasmapheresis
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- University of Louisville — Louisville, Kentucky, United States
- Univeristy of Michigan — Ann Arbor, Michigan, United States
- Nationwide Children's Medical Center — Columbus, Ohio, United States
- Pennsylvania State University Hersey Medical Center — Hershey, Pennsylvania, United States
- The Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States
- Seattle Children's Hospital — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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