Intracellular Tight Junction Permeability in Schizophrenia: Focus on Zonulin

Completed

Conditions studied: Schizophrenia, Celiac Disease

In brief

The purpose of this protocol is to collect serum zonulin levels in people with schizophrenia. This one time visit will collect zonulin levels, antibodies to gliadin (tissue transglutaminase and antigliadin antibodies) and other information that may relate to increased intracellular tight junction permeability as it related to the immune and stress system and the immune association with kynurenic acid pathway 50. Data will be collected for use in future grant applications and published reports.

Key facts

Study ID

NCT01558570

Run by

University of Maryland, Baltimore

People needed

100

Starts

2011-07-01

Expected to finish

2012-02-01

Last updated by the study team

2019-09-26

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• DSM-IV Diagnosis of Schizophrenia or Schizoaffective Disorder
• Male or females between ages of 18 to 75 years

You may not qualify if…

• Score below 10/12 on the Evaluation to Sign Consent (ESC)

Where it is running

• Maryland Psychiatric Research Center — Catonsville, Maryland, United States

Full record on ClinicalTrials.gov

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