Prediction of Response to Intra-articular Injections of Hyaluronic Acid for Knee Osteoarthritis

Completed · Phase 4

Conditions studied: Osteoarthritis, Knee

In brief

The purpose of this study is to evaluate whether the investigators can develop a computer algorithm to predict which individual patients will respond to injections of hyaluronic acid (HA) products for knee osteoarthritis.

Key facts

Study ID

NCT01557868

Run by

American Orthopaedic Society for Sports Medicine

People needed

198

Starts

2008-10-01

Expected to finish

2012-12-01

Last updated by the study team

2014-04-02

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Symptomatic knee osteoarthritis presenting to physician's office
• Radiographic evidence of knee osteoarthritis
• Age 18 years or older
• Failed minimum of 3 months of non-operative treatment, including, but not limited to, Tylenol, anti-inflammatory medication, cortisone injection, physical therapy, bracing, and/or heel wedge
• Symptoms for at least 3 months

You may not qualify if…

• Associated ligamentous instability
• History of deep knee infection
• Candidate for total knee arthroplasty or arthroscopy
• Peripheral neuropathy.
• X-rays that are completely negative and only MRI evidence or arthroscopic evidence (from previous arthroscopy) of OA.
• Prior HA injections at any point in the past
• Chondrocalcinosis
• Patients with precautions or contraindications for viscosupplementation use
• Cortisone injection within past 3 months

Where it is running

• Naval Medical Center Portsmouth (this site can only enroll patients who are eligible to be treated at a military facility) — Portsmouth, Virginia, United States

Full record on ClinicalTrials.gov

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