Neurocircuitry of Autism- fMRI and Transcranial Magnetic Stimulation Studies

Stopped early · Not applicable

Conditions studied: Autism Spectrum Disorder, Asperger Disorder, Pervasive Developmental Disorder

In brief

This study uses functional brain imaging and noninvasive brain stimulation techniques to study the brain basis of developmental disorders like Autism Spectrum Disorder and Asperger Disorder. Functional magnetic resonance imaging (fMRI) and recently approved FDA treatment of depression, Transcranial magnetic stimulation (TMS) will be used to study the neurocircuitry of certain symptom clusters in developmental disorders.

Key facts

Study ID

NCT01553240

Run by

New York State Psychiatric Institute

People needed

8

Starts

2007-06-01

Expected to finish

2010-06-01

Last updated by the study team

2017-01-13

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• for Healthy volunteer:
• no current psychiatric disorder meeting Axis 1 DSM-4 criteria.
• English speaking,
• verbal and full scale IQ > 65,
• capacity to give consent and signed HIPPA authorization.
• for Autism Spectrum Disorders:
• diagnosed with Autism, Asperger or Pervasive Developmental Disorder not otherwise specified,
• English speaking,
• capacity to give consent and verbal and full scale IQ > 65,
• signed HIPPA authorization,
• participants currently taking psychotropic medications must be at the same stable doses and be willing to continue at the same dose through out the study

You may not qualify if…

• for Healthy control and ASD:
• women of child bearing potential not using birth control pills or breast feeding,
• h/o bipolar disorder (lifetime),
• any psychotic disorder( lifetime),
• history of major depressive disorder or of substance abuse or dependence within the past year,
• verbal or full scale IQ less than or equal to 65,
• intracranial implants,
• metallic implants,
• shrapnel in the body,
• metallic braces,
• cardiac pacemakers or
• vagus nerve stimulation device,
• claustrophobia,
• prior dx of seizure,
• increased intracranial pressure or history of significant head trauma with loss of consciousness for at least 5 minutes
• current significant laboratory abnormality,
• neurological disorder including but not limited to space occupying brain lesion,
• any history of seizures,
• history of cerebrovascular accidents,
• fainting,
• cerebral aneurysm,
• dementia,
• huntington,
• chorea,
• multiple sclerosis

Where it is running

• New York state Psychiatric Institute — New York, New York, United States

Full record on ClinicalTrials.gov

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