Systemic Markers of Collagen Metabolism and Vitamin C in Smokers and Non-Smokers With Pelvic Organ Prolapse

Completed

Conditions studied: Pelvic Organ Prolapse

In brief

Data on smoking and POP are conflicting. In a study done by Alnaif et al, smoking was found to be associated with severe POP. The authors' proposed explanation was that smoking impairs tissue and wound healing. Our primary objective is to document whether smokers with pelvic organ prolapse (POP) are different from non-smokers with POP with respect to collagen biosynthesis and breakdown using systemic markers of collagen metabolism and Vitamin C.

Key facts

Study ID

NCT01548105

Run by

TriHealth Inc.

People needed

96

Starts

2012-03-01

Expected to finish

2013-03-01

Last updated by the study team

2014-10-17

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may not qualify if…

• Using Hormone Replacement Therapy (systemic estrogen, progesterone or testosterone)
• Using vaginal estrogen (cream, ring, tablet)
• Chronic steroid use
• Past medical history of connective tissue disease
• Scurvy, malabsorption, alcoholism, pregnancy, hyperthyroidism, liver disease and renal failure

Where it is running

• Good Samaritan Hospital — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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