MRI Study of Brain Activity in Healthy Adults and Individuals With Parkinsonism and Rapid Eye Movement Disorder.

Completed

Conditions studied: Movement Disorders (Incl Parkinsonism), Tremor Familial Essential, 1, REM Sleep Behavior Disorder

In brief

This proposal is focused on developing a reliable, valid, and reproducible imaging techniques and statistical methodology for segregation of various forms of Parkinsonism from healthy adults without Parkinsonism.

Key facts

Study ID

NCT01547481

Run by

University of Alabama at Birmingham

People needed

50

Starts

2011-12-01

Expected to finish

2015-12-31

Last updated by the study team

2018-05-17

Who can join

Age: 19 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy Control • Age 35-85
• Parkinson Disease (PD) Age 35-85
• Diagnosis of clinically definite PD made by a movement disorders specialist, with evidence of the following features:
• Presence of bradykinesia and 1 or both of the following:
• Rest tremor
• Rigidity
• Asymmetric Onset
• Progressive motor symptoms
• Levodopa responsive
• Duration at least 1 but not more than 10 years
• Hoehn and Yahr Stage 1-2
• Progressive Supranuclear Palsy (PSP) Age 40-85
• Diagnosis of clinically definite PSP, with the following features:
• Gradually progressive disorder.
• Onset after age 39
• Supranuclear palsy* and postural instability with falls in the first year of disease onset*.
• No evidence of other disease.
• Parkinsonism of Other or Undetermined Cause (POC) Age 35-85
• Diagnosis of parkinsonism of undetermined other other cause by a movement disorders specialist, with the following features:
• Signs and symptoms of Parkinsonism including
• Bradykinesia
• Mixed or resting tremor
• Rigidity
• Characteristic deficits of gait and balance associated with Parkinsonism
• Essential Tremor (ET) Age 35-85

You may not qualify if…

• Healthy Control
• Pregnancy
• First-degree blood relative affected by PD
• Neurodegenerative disease
• History of repeated head injury, encephalitis, brain surgery, stroke, dementia, neuroleptic exposure, or serious medical illness that may interfere with participation.
• Parkinson Disease (PD)
• Any exclusion criteria that would exclude a healthy control patient
• Atypical features indicative of a Parkinson-Plus disorder
• Progressive Supranuclear Palsy (PSP)
• Any exclusion criteria that would exclude a healthy control patient
• Any finding atypical for PSP
• Neuroradiologic evidence of relevant structural abnormality unrelated to appropriate changes known to be associated with PSP
• Parkinsonism of Other or Undetermined Cause (POC)
• Any exclusion criteria that would exclude a healthy control patient
• Signs and symptoms suggestive of clear diagnosis of idiopathic Parkinson disease, Progressive Supranuclear Palsy, or Essential Tremor
• Essential Tremor (ET)
• Any exclusion criteria that would exclude a healthy control patient
• No other potential etiologic factors for the tremor
• Any first-degree blood relative affected by PD
• History of neurodegenerative disease
• REM Behavior Disorder (RBD)
• Any exclusion criteria that would exclude a healthy control patient
• Sleep disorder not better explained by another sleep disorder, medical or neurological disorder, mental disorder, medication use, or substance use disorder

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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