Early Prevention of Preeclampsia Study

Stopped early · Not applicable · Has a placebo group

Conditions studied: Preeclampsia

In brief

This is a randomized controlled trial to estimate the efficacy of low dose aspirin for preventing preeclampsia in women identified as high risk. The investigators hypothesize that the risk of preeclampsia in women identified by a first trimester multiparameter predictive model to be at high risk will be significantly reduced by initiating low dose aspirin early in pregnancy.

Key facts

Study ID

NCT01547390

Run by

Washington University School of Medicine

People needed

104

Starts

2012-03-01

Expected to finish

2015-07-20

Last updated by the study team

2018-06-29

Who can join

Age: any. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Singleton pregnancy undergoing ultrasound examination at 9 0/7 - 14 6/7 weeks
• any one or more factors identified as high risk from the identified risk factors: Chronic hypertension, prepregnancy diabetes mellitus, previous preeclampsia, obesity (BMI >30), bilateral uterine artery notches preeclampsia risk score greater than 6, low PAPP-A ( < 0.52 MoM)

You may not qualify if…

• Multiple gestations,
• fetal aneuploidy
• major fetal structural anomaly
• bleeding disorder
• allergy to aspirin
• women already on aspirin or heparin.

Where it is running

• Washington University — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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