Cooperative Lifestyle Programs (CLIP-II)
Completed · Not applicable
Conditions studied: Cardiovascular Disease, Obesity, Physical Disability
In brief
The aim is to study the effects of weight loss and weight loss combined with different types of physical activity on changes in physical functioning of older adults who are at-risk for cardiovascular disease.
Key facts
- Study ID
- NCT01547182
- Run by
- Wake Forest University Health Sciences
- People needed
- 249
- Starts
- 2012-03-01
- Expected to finish
- 2016-10-01
- Last updated by the study team
- 2018-08-15
Who can join
Age: 60 and older, up to 79. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Residence: community-dwelling men and women from the counties of interest (SR)
- Age: between 60-79 yrs (SR)
- Activity Status: sedentary (less than 60 minutes of moderate intensity structured physical activity each week and occurs in no less than 10 minute blocks; SR)
- Adiposity: obese as defined by a BMI ≥ 30 (OAC)
- Medical Criteria: documented evidence of an MI, PCTI, chronic stable angina, cardiovascular surgery (coronary artery or valvular heart disease) or an ATP III diagnosis of the metabolic syndrome (PCP)
- Mobility Disability: disability defined as self-reported difficulty with walking ¼ mile, climbing stairs, lifting and carrying groceries, or performing other household chores such as cleaning and yard work (SR)
- Stability of Residence: does not plan to move out of the county of residence for the duration of the study (SR)
- Agreeableness: willing and able to participate in all aspects of the trial (SR)
- Consents: willing to give an informed consent and sign a HIPAA authorization form (SR)
You may not qualify if…
- Severe Symptomatic Heart Disease: evidence of unstable angina, symptomatic congestive heart failure, or exercise induced complex ventricular arrhythmias (PCP)
- MI or cardiovascular procedure within the last 3-months (PCP)
- Blood Pressure: a resting blood pressure > 160/100 mmHg (OAC)
- Severe Systemic Disease: diagnosis of Parkinson's disease, chronic liver disease (cirrhosis, chronic hepatitis, etc.), systemic rheumatic condition (rheumatoid arthritis, psoriatic arthritis, Reiter's disease, systemic lupus erythematosus, etc.), end stage renal disease or other systemic diseases or abnormal laboratory values which would preclude participants from safely participating in the protocol or impair their ability to complete the study (PCP)
- Cancer: active treatment for cancer other than non-melanotic skin cancer (PCP)
- Hearing or Sight Impairments: significant visual or hearing impairment that cannot be corrected and results in the inability to use the telephone or hear normal conversation (SR, OAC)
- Psychiatric Illness: bipolar depression or schizophrenia (defined as self-reported treatment for these conditions), currently receiving lithium or neuroleptics (PCP)
- Cognitive Impairment: dementia, delirium or impaired cognitive function as defined by a score on the Folstein Mini-Mental Status Exam < 21 (OAC)
- Participation in Other Trials: currently participating in or planning to participate in another medical intervention study (SR)
- Alcohol Intake: consuming more than 21 alcoholic drinks per week or alcoholism (SR)
- Functional Limitations: unable to walk unassisted (SR, OAC)
- English Literacy: unable to speak or read English
- Clinical Center Staff Evaluation: judged to be unsuitable for the trial for any reason by the clinic staff. A participant can be excluded prior to randomization because of some unspecified health problem that has been identified that would put the patient at risk for adherence or retention. These cases are discussed with a recruitment team consisting of the person who has raised the concern, an MD, and the study PIs.
Where it is running
- Kernersville YMCA. — Kernersville, North Carolina, United States
- William G. White YMCA — Winston-Salem, North Carolina, United States
- Fulton YMCA — Winston-Salem, North Carolina, United States
Full record on ClinicalTrials.gov
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