Hormone Therapy, Radiation Therapy, and Steroid 17alpha-monooxygenase TAK-700 in Treating Patients With High-Risk Prostate Cancer

Completed · Phase 3

Conditions studied: Prostate Cancer

In brief

RATIONALE: Androgens can cause the growth of prostate cancer cells. Drugs, such as steroid 17alpha-monooxygenase TAK-700, when used with other hormone therapy, may lessen the amount of androgens made by the body. Radiation therapy uses high energy x rays to kill tumor cells. This may be an effective treatment for prostate cancer when combined with hormone therapy. Studying quality-of-life in patients having cancer treatment may help identify the intermediate- and long-term effects of treatment on patients with prostate cancer. PURPOSE: This randomized phase III trial is studying the use of hormone therapy, including TAK-700, together with radiation therapy in treating patients with prostate cancer.

Key facts

Study ID

NCT01546987

Run by

Radiation Therapy Oncology Group

People needed

239

Starts

2012-05-01

Expected to finish

2025-09-04

Last updated by the study team

2026-03-06

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed diagnosis of adenocarcinoma of the prostate within 180 days prior to registration at high risk for recurrence as determined by one of the following combinations:
• Gleason Score (GS) ≥ 9, PSA ≤ 150 ng/mL, any T stage
• GS ≥ 8, PSA < 20 ng/mL, T stage ≥ T2
• GS ≥ 8, PSA ≥ 20-150 ng/mL, any T stage
• GS ≥ 7, PSA ≥ 20-150 ng/mL, any T stage
• History/physical examination within 60 days prior to registration.
• Clinically negative lymph nodes as established by imaging [abdominal and/or pelvic computerized tomography (CT) or abdominal and/or pelvic magnetic resonance imaging (MRI)], nodal sampling, or dissection within 90 days prior to registration.
• Patients with lymph nodes equivocal or questionable by imaging are eligible if the nodes are < 2.0 cm.
• No distant metastases (M0) on bone scan within 90 days prior to registration (18F-Na bone scan is an acceptable substitute).
• Equivocal bone scan findings are allowed if plain films are negative for metastasis.
• Baseline serum prostate-specific antigen (PSA) value performed with an FDA-approved assay (e.g., Abbott, Hybritech), obtained prior to any luteinizing hormone-releasing hormone (LHRH) or anti-androgen therapy, within 180 days of randomization.
• Androgen deprivation therapy (ADT), such as LHRH agonists (e.g., goserelin, leuprolide), anti-androgens (e.g., flutamide, bicalutamide), estrogens (e.g., DES), or surgical castration (orchiectomy), may have been started prior to registration, provided that registration is within 50 days of beginning ADT. Please note: If the patient has started ADT he will not be eligible to participate in the quality of life component of this study.
• Prior testosterone administration is allowed if last administered at least 90 days prior to registration.
• Zubrod Performance Status 0-1 within 21 days prior to registration
• Age ≥ 18
• Complete blood count (CBC)/differential obtained within 14 days prior to registration on study, with adequate bone marrow function defined as follows:
• Absolute neutrophil count (ANC) ≥ 1,800 cells/mm3
• Platelets ≥ 100,000 cells/mm3
• Hemoglobin ≥ 8.0 g/dl (Note: The use of transfusion or other intervention to achieve Hgb ≥ 8.0 g/dl is acceptable.)
• Serum creatinine < 2.0 mg/dl and creatinine clearance (can be calculated) > 40 mL/minute within 21 days prior to registration
• Bilirubin < 1.5x upper limit of normal (ULN) and alanine aminotransferase (ALT) or aspartate aminotransferase (AST) < 2.5x ULN within 21 days prior to registration
• Serum testosterone within 21 days prior to registration
• Chemistry (including sodium, potassium, chloride, bicarbonate (carbon dioxide), blood urea nitrogen (BUN), glucose, calcium, magnesium and phosphorous) and liver panels (including albumin and alkaline phosphatase) obtained within 21 days prior to registration
• Fasting glucose, fasting insulin, lipid panel [cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL)], and Hemoglobin A1C within 21 days prior to registration
• Screening calculated ejection fraction of ≥ to institutional lower limit of normal by multiple gated acquisition (MUGA) scan or by echocardiogram (ECHO).

You may not qualify if…

• PSA > 150
• Definite evidence of metastatic disease.
• Pathologically positive lymph nodes or nodes > 2.0 cm on imaging.
• Prior radical prostatectomy, cryosurgery for prostate cancer, or bilateral orchiectomy for any reason.
• Prior invasive malignancy (except non-melanoma skin cancer) unless disease-free or not requiring systemic therapy for a minimum of 3 years.
• Prior systemic chemotherapy for prostate cancer (Note that prior chemotherapy for a different cancer is allowed).
• Prior radiotherapy, including brachytherapy, to the region of the prostate that would result in overlap of radiation therapy fields.
• Any patient undergoing brachytherapy must have transrectal ultrasound confirmation of prostate volume <60 cc, American Urological Association (AUA) score ≤15 within 60 days of registration, and no history of prior transurethral resection of the prostate (TURP); prior TURP is permitted for patients who receive external beam radiation therapy [EBRT] only).
• Previous hormonal therapy for > 50 days.
• Known hypersensitivity to TAK-700 or related compounds
• A history of adrenal insufficiency
• History of myocardial infarction, unstable symptomatic ischemic heart disease, ongoing arrhythmias of Grade > 2 [NCI CTCAE, version 4.02] (U.S. Department of Health and Human Services, National Institutes of Health National Cancer Institute, 2009), thromboembolic events (eg, deep vein thrombosis, pulmonary embolism, or symptomatic cerebrovascular events), or any other cardiac condition (e.g., pericardial effusion restrictive cardiomyopathy) within 6 months prior to registration. Chronic stable atrial fibrillation on stable anticoagulant therapy is allowed.
• New York Heart Association Class III or IV heart failure.
• ECG abnormalities of:
• Q-wave infarction, unless identified 6 or more months prior to screening
• QTc interval > 460 msec
• Patients who are sexually active and not willing/able to use medically acceptable forms of contraception; this exclusion is necessary because the treatment involved in this study may be significantly teratogenic.
• Prior allergic reaction to the drugs involved in this protocol.
• Study entry PSA obtained during the following time frames:
• 10-day period following prostate biopsy;
• following initiation of hormonal therapy.
• Cushing's syndrome
• Severe chronic renal disease (serum creatinine > 2.0 mg/dl and confirmed by creatinine clearance < 40 mL/minute)
• Chronic liver disease (bilirubin > 1.5x ULN, ALT or AST > 2.5x ULN)
• Chronic treatment with glucocorticoids within one year

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• Arizona Oncology-Deer Valley Center — Phoenix, Arizona, United States
• Arizona Oncology Services Foundation — Scottsdale, Arizona, United States
• Sutter Cancer Centers Radiation Oncology Services-Auburn — Auburn, California, United States
• Sutter Cancer Centers Radiation Oncology Services-Cameron Park — Cameron Park, California, United States
• Mercy San Juan Medical Center — Carmichael, California, United States
• Veterans Administration Long Beach Medical Center — Long Beach, California, United States
• Los Angeles County-USC Medical Center — Los Angeles, California, United States
• University of Southern California/Norris Cancer Center — Los Angeles, California, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States
• Pomona Valley Hospital Medical Center — Pomona, California, United States
• Rohnert Park Cancer Center — Rohnert Park, California, United States
• Sutter Cancer Centers Radiation Oncology Services-Roseville — Roseville, California, United States
• Sutter General Hospital — Sacramento, California, United States
• University of California At San Diego — San Diego, California, United States
• UCSF-Mount Zion — San Francisco, California, United States
• Kaiser Permanente Medical Center - Santa Clara — Santa Clara, California, United States
• Kaiser Permanente Cancer Treatment Center — South San Francisco, California, United States
• Stanford University Hospitals and Clinics — Stanford, California, United States
• Sutter Cancer Centers Radiation Oncology Services-Vacaville — Vacaville, California, United States
• Sutter Solano Medical Center — Vallejo, California, United States
• University of Colorado Cancer Center - Anschutz Cancer Pavilion — Aurora, Colorado, United States
• Poudre Valley Radiation Oncology — Fort Collins, Colorado, United States
• Hartford Hospital — Hartford, Connecticut, United States
• The Kirklin Clinic at Acton Road — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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