Coronary Artery Study in Pediatric Heart Transplantation

Withdrawn before enrolling

Conditions studied: Transplant Coronary Artery Disease

In brief

Transplant coronary artery disease (TCAD) is a significant cause of morbidity and mortality in pediatric heart transplantation (PHT). Understanding the pathophysiology and early detection along with attempted medical management are crucial in preventing advancement of the disease and retransplantation or mortality. Coronary angiogram, although routinely used is insensitive to detect early TCAD. Measurement of fractional flow reserve (FFR), coronary flow reserve (CFR) and index of microvascular resistance (IMR) using a doppler pressure and flow intracoronary wire may be more sensitive in evaluating the integrity of coronary vasculature and thus detect pre clinical TCAD. To the best of the investigators knowledge, measurement of these parameters has not been previously reported in PHT.

Key facts

Study ID

NCT01546870

Run by

Arkansas Children's Hospital Research Institute

People needed

0

Starts

2012-04-01

Expected to finish

2012-04-01

Last updated by the study team

2016-06-20

Who can join

Age: 7 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• less than 21 years and above 7 years of age

You may not qualify if…

• clinically significant coronary artery disease on angiography and inability to undergo IVUS

Where it is running

• Arkansas Children's hospital — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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