Stepwise Approach To sUbstrate Modification for Ventricular Tachycardia

Stopped early · Not applicable

Conditions studied: Ventricular Tachycardia, Catheter Ablation, Tachycardia, Ventricular

In brief

The goal of this trial is to test the impact of a step-wise approach for catheter ablation of recurrent ventricular tachycardia, (irregular heart rhythms that originate in the bottom chambers of the heart), in patients with a previous heart attack for whom catheter ablation is clinically indicated.

Key facts

Study ID

NCT01546207

Run by

Vivek Reddy

People needed

4

Starts

2011-09-01

Expected to finish

2013-08-01

Last updated by the study team

2020-01-13

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 to 90 years.
• History of coronary artery disease.
• Presence of, or planned for, an ICD prior to discharge.
• Presentation for management of ICD shock/ATP therapy or monomorphic ventricular tachycardia.

You may not qualify if…

• Ventricular arrhythmia not thought to be due to CAD.
• Unstable angina
• CVA within 30 days.
• Protruding left ventricular thrombus or critical aortic stenosis on pre-ablation echocardiography
• Pregnancy
• Any condition resulting in an absolute contraindication to anticoagulation
• Inability to follow-up at ICD clinic.
• Inability to give informed consent.
• Non-inducible for sustained monomorphic ventricular tachycardia.
• Prior substrate guided ablation.
• Definite need for epicardial ablation, as determined by the primary operator.

Where it is running

• University of Alabama - Birmingham — Birmingham, Alabama, United States
• Loyola University — Maywood, Illinois, United States
• Brigham & Women's Hospital — Boston, Massachusetts, United States
• Beth Israel-Deaconess Medical Center — Boston, Massachusetts, United States
• Icahn School of Medicine at Mount Sinai — New York, New York, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Hospital Regional Sao Jose — Santa Catarina, Brazil
• Southlake Regional Health Center — Newmarket, Ontario, Canada
• Homolka Hospital — Prague, Czechia
• San Raffaele Hospital — Milan, Italy

Full record on ClinicalTrials.gov

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