The Influence of Pressure Pain on [11C]Diprenorphine Binding Potentials

Completed · Not applicable

Conditions studied: Healthy Controls

In brief

Healthy volunteers aged 21 to 50 are needed for a research study investigating whether pain will alter the binding properties of (\[11C\]diprenorphine), a molecule that can be used during brain imaging. Positron Emission Tomography (PET) and functional Magnetic Resonance (fMRI) imaging will be used in this study.

Key facts

Study ID

NCT01546155

Run by

Massachusetts General Hospital

People needed

11

Starts

2011-12-01

Expected to finish

2015-12-01

Last updated by the study team

2017-04-11

Who can join

Age: 21 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy male and female adults, 21 to 50 years of age
• No contraindications to fMRI and PET scanning
• Within 15% of ideal body mass index (BMI)

You may not qualify if…

• Current significant medical, neurological, or psychiatric illness as assessed by the Physician Investigators
• Women who are pregnant or breast feeding, have gone through menopause, and/or have irregular menstrual cycles
• Claustrophobia
• History of head trauma
• Instability of responses to experimental pain (See Study Procedure Section Part II)
• History of asthma
• Use of psychotropic drugs or hormone treatments (including hormonal birth control) within one year of date of consent
• History of smoking
• Routine exercise in excess of one hour per day and/or three times per week
• Non-fluent English speaker

Where it is running

• Massachusetts General Hospital — Charlestown, Massachusetts, United States

Full record on ClinicalTrials.gov

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