Testing the Developmental Origins Hypothesis
Status unconfirmed
Conditions studied: Diabetes, Stroke, Obesity
In brief
INTRODUCTION: CHIPS-Child is a parallel, ancillary study to the CHIPS randomized controlled trial (RCT). CHIPS is designed to determine whether 'less tight' control \[target diastolic BP (dBP) 100mmHg\] or 'tight' control \[target dBP 85mmHg\] of non-proteinuric hypertension in pregnancy is better for the baby without increasing maternal risk. CHIPS-Child is a follow up study at 12 m corrected post-gestational age (± 2 m) limited to non-invasive examination \[anthropometry, hair cortisol, buccal swabs for epigenetic testing and a maternal questionnaire about infant feeding practices and background\]. Annual contact will be maintained in years 2-5 and contact will include annual parental measurement of the child's height, weight and waist circumference. OBJECTIVE: To directly test, for the first time in humans, whether differential blood pressure (BP) control in pregnancy has developmental programming effects, independent of birthweight. We predict that, like famine or protein malnutrition, 'tight' (vs. 'less tight') control of maternal BP will be associated with fetal under-nutrition and effects will be consistent with developmental programming.
Key facts
- Study ID
- NCT01545492
- Run by
- Children's & Women's Health Centre of British Columbia
- People needed
- 626
- Starts
- 2012-01-01
- Expected to finish
- 2019-01-01
- Last updated by the study team
- 2012-03-06
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All women participating in CHIPS and their children born after recruitment.
You may not qualify if…
- Women who have experienced the loss of their pregnancy or child after recruitment into CHIPS.
Where it is running
- Yale-New Haven Hospital — New Haven, Connecticut, United States (enrolling)
- Norton Hospital Downtown & Suburban — Louisville, Kentucky, United States (enrolling)
- Copper University Hospital — Camden, New Jersey, United States (enrolling)
- Oregon Health & Science University — Portland, Oregon, United States (enrolling)
- Ipswich Hospital — Ipswich, Australia (enrolling)
- King Edward Memorial Hospital — Subiaco, Australia (enrolling)
- Royal Alexandra Hospital — Edmonton, Alberta, Canada (enrolling)
- Surrey Memorial Hospital: Jim Pttison Outpatient Care & Surgery Centre — Surrey, British Columbia, Canada (enrolling)
- BC Children & Women's Health Centre — Vancouver, British Columbia, Canada (enrolling)
- IWK Health Centre — Halifax, Nova Scotia, Canada (enrolling)
- London Health Sciences Centre — London, Ontario, Canada (enrolling)
- CHUS Fleurimont — Sherbrooke, Ontario, Canada (enrolling)
- Sunnybrook Health Sciences Centre — Toronto, Ontario, Canada (enrolling)
- Hopital Sainte-Justine — Montreal, Quebec, Canada (enrolling)
- Royal University Hospital — Saskatoon, Saskatchewan, Canada (enrolling)
- Hospital Base Osorno — Osorno, Chile (enrolling)
- Hospital Dr Sotero del Rio — Puente Alto, Chile (enrolling)
- Tartu University Hospital - Women's Clinic — Tartu, Estonia (enrolling)
- Academic Medical Center — Amsterdam, Netherlands (enrolling)
- OLVG — Amsterdam, Netherlands (enrolling)
- VU Medical Center — Amsterdam, Netherlands (enrolling)
- UMCG — Groningen, Netherlands (enrolling)
- Tergooiziekenhuizen — Hilversum, Netherlands (enrolling)
- MUMC Maastricht — Maastricht, Netherlands (enrolling)
- St Antonius Ziekenhuis — Nieuwegein, Netherlands (enrolling)
Full record on ClinicalTrials.gov
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