A Study of Lebrikizumab in Patients Whose Asthma is Uncontrolled With Inhaled Corticosteroids and A Second Controller Medication (LUTE)

Completed · Phase 2 · Has a placebo group

Conditions studied: Asthma

In brief

This randomized, multicenter, double-blind, placebo-controlled, parallel-group study will assess the efficacy and safety of lebrikizumab in patients with asthma whose disease remains uncontrolled despite daily therapy with an inhaled corticosteroid and a second controller medication. Patients will be randomized in a 1:1:1:1 ratio to receive double-blind treatment with subcutaneous lebrikizumab ("highest", "middle", "lowest" dose) or placebo every 4 weeks for 52 weeks, in addition to their standard-of-care therapy. This will be followed by a 52-week double-blind active treatment extension. The anticipated time on study treatment is up to 104 weeks. There will be a safety follow-up of 24 weeks after the last dose of study drug for all patients.

Key facts

Study ID

NCT01545440

Run by

Genentech, Inc.

People needed

258

Starts

2012-03-01

Expected to finish

2013-07-01

Last updated by the study team

2015-03-05

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients, 18 to 75 years of age at Visit 1
• Asthma diagnosis for >/= 12 months prior to the start of screening (Visit 1)
• Bronchodilator response during screening
• Pre-bronchodilator FEV1 40%-80% of predicted during screening
• On ICS (inhaled corticosteroids) 500-2000 mcg/day of fluticasone propionate DPI or equivalent for >/= 6 months prior to the start of screening (Visit 1) with no anticipated changes throughout the study
• On an eligible second controller medication (LABA, LAMA, LTRA or theophylline within the prescribed dosing range)
• Uncontrolled asthma as defined by protocol both during screening period and at time of randomization
• Chest X-ray or computed tomography (CT) scan obtained within 12 months prior to screening or chest X-ray during screening period confirming the absence of other lung disease
• Demonstrated adherence with controller medication during the screening period

You may not qualify if…

• History of severe allergic or anaphylactic reaction to a biologic agent or known hypersensitivity to any component of the lebrikizumab injection
• Use of zileuton or roflumilast within 6 months prior to screening
• Maintenance oral corticosteroid therapy, defined as daily or alternate day oral corticosteroid maintenance therapy within the 3 months prior to Visit 1
• Treatment with systemic (oral, intravenous or intramuscular) corticosteroids within the 4 weeks prior to Visit 1
• Major episode of infection within 4 weeks prior to Visit 1 or treatment with oral antibiotics within 2 weeks prior to Visit 1
• Active parasitic infection within the 6 months prior to Visit 1
• Active tuberculosis requiring treatment within the 12 months prior to Visit 1
• Known immunodeficiency, including, but not limited to, HIV infection
• Evidence of acute or chronic hepatitis or known liver cirrhosis
• History of cystic fibrosis, chronic obstructive pulmonary disease, and/or other clinically significant lung disease other than asthma
• Known malignancy or current evaluation for a potential malignancy
• Current smoker or former smoker with a history >10 pack years
• History of alcohol, drug or chemical abuse
• Initiation or change in allergen immunotherapy within 3 months prior to Visit 1
• Use of biologic therapy including omalizumab during 6 months prior to Visit 1
• Receipt of live/attenuated vaccine within 4 weeks prior to Visit 1
• Pregnant or lactating women
• Body mass index (BMI) > 38 kg/m2
• Body weight < 40 kg

Where it is running

• Study site — Scottsdale, Arizona, United States
• Study site — Scottsdale, Arizona, United States
• Study site — Tucson, Arizona, United States
• Study site — Bakersfield, California, United States
• Study site — Fountain Valley, California, United States
• Study site — Fullerton, California, United States
• Study site — Los Angeles, California, United States
• Study site — Los Angeles, California, United States
• Study site — Mission Viejo, California, United States
• Study site — Napa, California, United States
• Study site — Orange, California, United States
• Study site — Rancho Mirage, California, United States
• Study site — Sacramento, California, United States
• Study site — San Diego, California, United States
• Study site — Studio City, California, United States
• Study site — Upland, California, United States
• Study site — Walnut Creek, California, United States
• Study site — Centennial, Colorado, United States
• Study site — Colorado Springs, Colorado, United States
• Study site — Denver, Colorado, United States
• Study site — Wheat Ridge, Colorado, United States
• Study site — Waterbury, Connecticut, United States
• Study site — Gainesville, Florida, United States
• Study site — North Palm Beach, Florida, United States
• Study site — Pell City, Alabama, United States

Full record on ClinicalTrials.gov

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